INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY

Sabir Jacquir (1) , Stéphane Binczak (1) , Binbin Xu (1) , Gabriel Laurent (1) , David Vandroux (2) , Pierre Athias (3) , Jean-Marie Bilbault (1)

1 Le2i - Laboratoire Electronique, Informatique et Image [UMR6306]
2 NVH - NVH Medicinal
3 LPPCE - Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale

During cardiac arrhythmia, functional reentries may take the form of spiral waves. The purpose of this study was to induce spiral waves by an electrical stimulation of cultured neonatal rat cardiomyocytes using a microelectrode arrays technology. In basal conditions, cardiac muscle cells in monolayer culture displayed a planar wavefront propagation. External electrical impulse trains induced severe arrhythmia and spiral waves appeared. This in vitro generation of spiral wave opens a new way to test the anti-arrhythmic drugs and for strategies at microscopically scale.

Mots clés: Spiral wave; MicroElectrode Array (MEA) Technology; Cardiac cells; Fibrillation.; Fibrillation

Domaines: Systèmes dynamiques [math.DS]; Dynamique Chaotique [nlin.CD]; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]; Cardiologie et système cardiovasculaire

Sabir Jacquir, Stéphane Binczak, Binbin Xu, Gabriel Laurent, David Vandroux, et al.. INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY. International journal of bifurcation and chaos in applied sciences and engineering , 2011, 21 (1), pp.209-223. ⟨10.1142/S0218127411028374⟩. ⟨hal-00585901⟩