Biomarker in Active Surveillance for Prostate Cancer: A Systematic Review - Institut Bergonié Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2021

Biomarker in Active Surveillance for Prostate Cancer: A Systematic Review

Cécile Manceau
  • Fonction : Auteur
  • PersonId : 1110791
Laurent Brureau
  • Fonction : Auteur
  • PersonId : 1110792
Gilles Créhange
  • Fonction : Auteur
  • PersonId : 1110793
Guilhem Roubaud
  • Fonction : Auteur
  • PersonId : 975634
Paul Sargos
  • Fonction : Auteur
  • PersonId : 1042270

Résumé

Active surveillance (AS) in prostate cancer (PCa) represents a curative alternative for men with localised low-risk PCa. Continuous improvement of AS patient’s selection and surveillance modalities aims at reducing misclassification, simplifying modalities of surveillance and decreasing need for invasive procedures such repeated biopsies. Biomarkers represent interesting tools to evaluate PCa diagnosis and prognosis, of which many are readily available or under evaluation. The aim of this review is to investigate the biomarker performance for AS selection and patient outcome prediction. Blood, urinary and tissue biomarkers were studied and a brief description of use was proposed along with a summary of major findings. Biomarkers represent promising tools which could be part of a more tailored risk AS strategy aiming to offer personalized medicine and to individualize the treatment and monitoring of each patient. The usefulness of biomarkers has mainly been suggested for AS selection, whereas few studies have investigated their role during the monitoring phase. Randomized prospective studies dealing with imaging are needed as well as larger prospective studies with long-term follow-up and strong oncologic endpoints.
Fichier principal
Vignette du fichier
cancers-13-04251-v2.pdf (887.26 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03350793 , version 1 (21-09-2021)

Identifiants

Citer

Cécile Manceau, Gaëlle Fromont, Jean-Baptiste Beauval, Eric Barret, Laurent Brureau, et al.. Biomarker in Active Surveillance for Prostate Cancer: A Systematic Review. Cancers, 2021, 13 (17), pp.4251. ⟨10.3390/cancers13174251⟩. ⟨hal-03350793⟩
70 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More