The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms - Archive ouverte HAL Access content directly
Journal Articles Leukemia Year : 2022

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

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Joseph D. Khoury
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Oussama Abla
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Yassmine M.N. Akkari
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Rita D. Alaggio
J. Apperley
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Rafael Bejar
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Emilio Berti
Lambert Busque
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John K.C. Chan
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Weina Chen
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Xueyan Chen
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Wee Joo Chng
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John K. Choi
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Isabel Colmenero
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S. E. Coupland
Nicholas C.P. Cross
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Daphne D. de Jong
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Mohamed Tarek Elghetany
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Emiko Takahashi
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Judith Ann Ferry
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Linda Fogelstrand
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Ulrich Germing
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Sumeet Gujral
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Torsten Haferlach
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Claire N. Harrison
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Jennelle C. Hodge
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Shimin Hu
Joop H. Jansen
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Rashmi Kanagal-Shamanna
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Hagop M. Kantarjian
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Christian Peter Kratz
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Xiaoqiu Li
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Megan S. Lim
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Keith R. Loeb
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Sanam Loghavi
Andrea N. Marcogliese
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Soheil Meshinchi
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Phillip D. Michaels
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Kikkeri N. Naresh
Yasodha Natkunam
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Reza Nejati
German K. Ott
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Eric Padron
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Keyur Pravinchandra Patel
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Nikhil Patkar
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Jennifer Lee Picarsic
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Uwe Platzbecker
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Irene Roberts
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Anna Schuh
William Sewell
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Reiner Siebert
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Prashant Ramesh Tembhare
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Jeffrey W. Tyner
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Srdan Verstovsek
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Wei Wang
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Brent Lee Wood
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Wenbin Xiao
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Cecilia Ching Sze Yeung
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Andreas Hochhaus
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Abstract

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
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Origin : Publication funded by an institution

Dates and versions

hal-03775750 , version 1 (28-10-2022)

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Attribution - CC BY 4.0

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Joseph D. Khoury, Éric Solary, Oussama Abla, Yassmine M.N. Akkari, Rita D. Alaggio, et al.. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia, 2022, 36 (7), pp.1703-1719. ⟨10.1038/s41375-022-01613-1⟩. ⟨hal-03775750⟩
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