Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application - Institut Pasteur de Lille Accéder directement au contenu
Article Dans Une Revue Materials Science and Engineering: C Année : 2019

Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application

Résumé

The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.
Fichier principal
Vignette du fichier
S0928493118329515.pdf (1.83 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02114423 , version 1 (22-10-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Francois Aubert-Viard, Alejandra Mogrovejo Valdivia, Nicolas Tabary, Mickael Maton, Feng Chai, et al.. Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application. Materials Science and Engineering: C, 2019, Materials Science and Engineering: C, 100, pp.554-563. ⟨10.1016/j.msec.2019.03.044⟩. ⟨hal-02114423⟩
46 Consultations
72 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More