Significant Need for a French Network of Expert Centers Enabling a Better Characterization and Management of Treatment-Resistant Depression (Fondation FondaMental)

Antoine Yrondi (1) , Djamila Bennabi (2) , Emmanuel Haffen (3) , Marion Garnier (4, 5) , Frank Bellivier (5) , Thierry Bourgerol (6) , Vincent Camus (7) , Thierry D’amato (5) , Olivier Doumy (8) , Frédéric Haesebaert (5) , Jérôme Holtzmann (5) , Christophe Lançon (9) , Philippe Vignaud (10) , Fanny Moliere (11) , Isabel Nieto (5) , Raphaëlle Marie Richieri (12) , Philippe Domenech (13) , Corentin Rabu (14, 5) , Luc Mallet (15) , Liova Yon (16) , Laurent Schmitt (17) , Florian Stéphan (18) , Guillaume Vaiva (19) , Michel Walter (20) , Pierre-Michel Llorca (21) , Philippe Courtet (11) , Marion Leboyer (16) , Wissam El-Hage (22) , Bruno Aouizerate (8)

1 ToNIC - Toulouse NeuroImaging Center
2 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
3 Département de psychiatrie [CHRU de Besançon]
4 CHU Clermont-Ferrand
5 Fondation FondaMental [Créteil]
6 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
7 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
8 Centre hospitalier Charles Perrens [Bordeaux]
9 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
10 Centre Hospitalier le Vinatier [Bron]
11 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
12 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
13 ISC - Institut des Sciences Cognitives
14 Hôpital Henri Mondor
15 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
16 IMRB - Institut Mondor de Recherche Biomédicale
17 LIVE - Laboratoire Image, Ville, Environnement
18 LNB - Laboratoire de Neurosciences de Brest
19 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies
20 CHU - Brest- Psychiatrie - CHRU Brest - Psychiatrie Adulte
21 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
22 Clinique Psychiatrique Universitaire [Tours]

Background: Major depression is characterized by (i) a high lifetime prevalence of 16-17% in the general population; (ii) a high frequency of treatment resistance in around 20-30% of cases; (iii) a recurrent or chronic course; (iv) a negative impact on the general functioning and quality of life; and (v) a high level of comorbidity with various psychiatric and non-psychiatric disorders, high occurrence of completed suicide, significant burden along with the personal, societal, and economic costs. In this context, there is an important need for the development of a network of expert centers for treatment-resistant depression (TRD), as performed under the leadership of the Fondation FondaMental.

Mots clés: treatment-resistant depression; depressive disorder; assessment; network; innovative strategies; treatment-resistant depression

Domaines: Sciences du Vivant [q-bio]

Antoine Yrondi, Djamila Bennabi, Emmanuel Haffen, Marion Garnier, Frank Bellivier, et al.. Significant Need for a French Network of Expert Centers Enabling a Better Characterization and Management of Treatment-Resistant Depression (Fondation FondaMental). Frontiers in Psychiatry, 2017, 8, ⟨10.3389/fpsyt.2017.00244⟩. ⟨hal-02514024⟩