Skip to Main content Skip to Navigation
Theses

Impact des modalités d'un exercice physique sur la neuroplasticité. Focus sur les sources de BDNF

Abstract : Physical exercise (EX) is recognized as the most potent non-pharmacological strategy to positively enhance brain health. From Human and animal studies there is a consensus to involve brain-derived neurotrophic factor (BDNF), a neurotrophin strongly expressed in response to EX and implicated in neuroplasticity mechanisms. Mainly expressed by neurons, BDNF is also expressed by endothelial and muscle cells. Largely sought during a physical effort, endothelium and skeletal muscle could be involved in positive effects induced by EX. Although there is a real consensus about BDNF and cerebral effect of EX, the typology of the better regimen of EX to enhance cerebral plasticity is not known. In this context, objectives of this works were to determine the impact of EX modalities on BDNF protein expression in different territory (brain, endothelium and muscle) and to identify mechanisms related in BDNF increases in response to EX.Our results showed that 1) BDNF expression in peripheral vessels from the same vascular territory (distinct internal diameter) is similar in response to EX, 2) cerebral BDNF increases induced by EX is dependent on EX intensity but not on the type of contraction (eccentric/concentric), 3) memory is restored by high intensity EX, 4) after EX, BDNF muscular expression is unchanged while the precursor of irisine (FNDC5) expression is increased, 5) BDNF expression depends on muscular fibers typology, 6) cerebral beneficial effects of EX intensity is might not be related to muscular irisine production.In conclusion, our data demonstrated that EX positively impact endothelial, cerebral but not muscular BDNF expression. Results highlighted the importance of the intensity parameter of EX on cerebral BDNF levels. Finally, according to our data, irisine and BDNF from the muscle might not be related to the cerebral increases of BDNF induced by EX intensity.
Document type :
Theses
Complete list of metadata

Cited literature [384 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02402708
Contributor : Abes Star :  Contact
Submitted on : Tuesday, December 10, 2019 - 3:37:19 PM
Last modification on : Friday, October 23, 2020 - 5:00:38 PM
Long-term archiving on: : Wednesday, March 11, 2020 - 8:19:01 PM

File

79340_CEFIS_2019_archivage.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02402708, version 1

Collections

Citation

Marina Cefis. Impact des modalités d'un exercice physique sur la neuroplasticité. Focus sur les sources de BDNF. Biochimie, Biologie Moléculaire. Université Bourgogne Franche-Comté, 2019. Français. ⟨NNT : 2019UBFCK049⟩. ⟨tel-02402708⟩

Share

Metrics

Record views

356

Files downloads

745