Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats.

Abstract : Although brain-derived neurotrophic factor (BDNF) plays a central role in recovery after cerebral ischemia, little is known about cells involved in BDNF production after stroke. The present study testes the hypothesis that neurons are not the unique source of neosynthesized BDNF after stroke and that non neuronal-BDNF producing cells differ according to the delay after stroke induction. For this purpose, cellular localization of BDNF and BDNF content of each hemisphere were analysed in parallel before and after (4h, 24h and 8d) ischemic stroke in rats. Stroke of different severities was induced by embolization of the brain with variable number of calibrated microspheres allowing us to explore the association between BDNF production and neuronal death severity. The main results are that (a) unilateral stroke increased BDNF production in both hemispheres with a more intense and long-lasting effect in the lesioned hemisphere, (b) BDNF levels either of the lesioned or unlesioned hemispheres were not inversely correlated to neuronal death severity whatever the delay after stroke onset, (c) in the unlesioned hemisphere, stroke resulted in increased BDNF staining in neurons and ependymal cells (at 4h and 24h), (d) in the lesioned hemisphere, beside neurons and ependymal cells, microglial cells (at 24h), endothelial cells of cerebral arterioles (at 4h and 24h) and astrocytes (at 8d) exhibited a robust BDNF staining as well. Taken together, overall data suggest that non neuronal cells are able to produce substantial amount of BDNF after ischemic stroke and that more attention should be given to these cells in the design of strategies aimed at improving stroke recovery through BDNF-related mechanisms.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [58 références]  Voir  Masquer  Télécharger
Contributeur : Philippe Garnier Connectez-vous pour contacter le contributeur
Soumis le : vendredi 25 mai 2012 - 15:43:27
Dernière modification le : mardi 19 octobre 2021 - 11:05:36
Archivage à long terme le : : dimanche 26 août 2012 - 02:27:30


Fichiers produits par l'(les) auteur(s)




Yannick Béjot, Anne Tessier, Claire Cachia, Maurice Giroud, Claude Mossiat, et al.. Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats.. Neurochemistry International, 2011, 58 (1), pp.102-11. ⟨10.1016/j.neuint.2010.10.019⟩. ⟨hal-00701314⟩



Consultations de la notice


Téléchargements de fichiers