Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Developmental toxic potential of di-n-propyl phthalate administered orally to rats.

Anne-Marie Saillenfait * Alain-Claude Roudot 1 Frédéric Gallissot Jean-Philippe Sabaté Marie-Christine Chagnon 2, 3
* Auteur correspondant
2 Derttech Packtox
LNC - Lipides - Nutrition - Cancer (U866), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
Abstract : The objective of this study was to evaluate the developmental toxic potential of di-n-propyl phthalate (DnPP) in rats. Pregnant Sprague-Dawley rats were given DnPP at doses of 0 (olive oil), 0.5, 1 and 1.5 g kg⁻¹ per day, by gavage, on gestation days 6-20. Benchmark doses were calculated for the effects of DnPP on fetal weight and anogenital distance of the male fetuses. Maternal body weight gain was significantly reduced at 1.5 g kg⁻¹ per day, over gestation days 6-9. DnPP-treated dams also showed a statistically significant increase in liver weight and a mild but statistically significant peroxisomal enzyme induction at 1 or 1.5 g kg⁻¹ per day. Male and female fetal body weights were significantly reduced at 1.5 g kg⁻¹ per day. There was a statistically significant decrease in the anogenital distance of the male fetuses at 1 and 1.5 g kg⁻¹ per day, and three males (of 75) showed malpositioned testis at the high dose. The mean percentage of fetuses per litter with cervical and thoracic rudimentary ribs was significantly increased at 1 and 1.5 g kg⁻¹ per day. Delayed ossification was seen at 1 g kg⁻¹ per day (phalanges) and 1.5 g kg⁻¹ per day (hyoid, sternebrae, and phalanges). No treatment-related effects on prenatal viability or on fetal external or visceral malformations or variations were observed at any dose. Thus, there was no evidence of teratogenicity up to the high dose of 1.5 g kg⁻¹ per day. The no-observed-adverse-effect level (NOAEL) for developmental toxicity was 0.5 g kg⁻¹ per day.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00723070
Contributeur : Sabine Julien <>
Soumis le : mardi 7 août 2012 - 14:03:56
Dernière modification le : vendredi 5 juin 2020 - 09:28:03

Lien texte intégral

Identifiants

Citation

Anne-Marie Saillenfait, Alain-Claude Roudot, Frédéric Gallissot, Jean-Philippe Sabaté, Marie-Christine Chagnon. Developmental toxic potential of di-n-propyl phthalate administered orally to rats.. Journal of Applied Toxicology, Wiley, 2011, 31 (1), pp.36-44. ⟨10.1002/jat.1565⟩. ⟨hal-00723070⟩

Partager

Métriques

Consultations de la notice

280