Coenzyme Q as an antiadipogenic factor.

Sandy Bour 1 Maria-Carmen Carmona Anne Galinier 2 Sylvie Caspar-Bauguil Luc van Gaal 3 Bart Staels 4 Luc Pénicaud 5 Louis Casteilla 2, *
* Auteur correspondant
1 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
2 NPTME - Neurobiologie, plasticité tissulaire et métabolisme énergétique
3 Antwerp University Hospital
4 EGID - Récepteurs nucléaires, maladies cardiovasculaires et diabète
5 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
Abstract : Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice. We sought to determine (i) whether this deficit exists in all species and its relevance in human obesity and (ii) to what extent CoQ could be involved in adipocyte differentiation. Here we identified in rodents as well as in humans a specific very strong nonlinear negative correlation between CoQ content in subcutaneous adipose tissue and obesity indexes. This striking correlation reveals a threshold value similar in both species. This relative deficit in CoQ content in adipose tissue rapidly took place during the time course of high-fat-diet-induced obesity in mice. Adipocyte differentiation was assessed in vitro using the preadipocyte 3T3-F442A cell line. When CoQ synthesis was inhibited by a pharmacological approach using chlorobenzoic acid, this strongly triggered adipose differentiation. In contrast, adipogenesis was strongly inhibited when a long-term increase in CoQ content was obtained by overexpressing human 4-hydroxy benzoate acid polyprenyltransferase gene. Altogether, these data suggest that a strict level of CoQ remains essential for adipocyte differentiation, and its impairment is associated with obesity.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00825015
Contributeur : Sabine Julien <>
Soumis le : mercredi 22 mai 2013 - 17:10:45
Dernière modification le : mercredi 19 février 2020 - 14:33:22

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Sandy Bour, Maria-Carmen Carmona, Anne Galinier, Sylvie Caspar-Bauguil, Luc van Gaal, et al.. Coenzyme Q as an antiadipogenic factor.. Antioxidants and Redox Signaling, Mary Ann Liebert, 2011, 14 (3), pp.403-13. ⟨10.1089/ars.2010.3350⟩. ⟨hal-00825015⟩

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