Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Cytotoxic dendritic cells generated from cancer patients.

Abstract : Known for years as professional APCs, dendritic cells (DCs) are also endowed with tumoricidal activity. This dual role of DC as killers and messengers may have important implications for tumor immunotherapy. However, the tumoricidal activity of DCs has mainly been investigated in animal models. Cancer cells inhibit antitumor immune responses using numerous mechanisms, including the induction of immunosuppressive/ tolerogenic DCs that have lost their ability to present Ags in an immunogenic manner. In this study, we evaluated the possibility of generating tumor killer DCs from patients with advanced-stage cancers. We demonstrate that human monocyte-derived DCs are endowed with significant cytotoxic activity against tumor cells following activation with LPS. The mechanism of DC-mediated tumor cell killing primarily involves peroxynitrites. This observed cytotoxic activity is restricted to immature DCs. Additionally, after killing, these cytotoxic DCs are able to activate tumor Ag-specific T cells. These observations may open important new perspectives for the use of autologous cytotoxic DCs in cancer immunotherapy strategies.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [68 références]  Voir  Masquer  Télécharger

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00828336
Contributeur : Catherine Vergely <>
Soumis le : jeudi 30 mai 2013 - 17:03:45
Dernière modification le : mardi 27 octobre 2020 - 14:35:49
Archivage à long terme le : : samedi 31 août 2013 - 08:30:15

Fichier

Lakomy_2011.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Daniela Lakomy, Nona Janikashvili, Jennifer Fraszczak, Malika Trad, Sylvain Audia, et al.. Cytotoxic dendritic cells generated from cancer patients.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (5), pp.2775-82. ⟨10.4049/jimmunol.1004146⟩. ⟨hal-00828336⟩

Partager

Métriques

Consultations de la notice

860

Téléchargements de fichiers

1266