Abstract : Motion induced artifacts represent a major obstacle in the correct malignant lesion detection in medical imaging especially in MRI. The goal of this paper is to evaluate the performance of a new non-rigid motion correction algorithm based on the optical flow method. The proposed algorithm specifically addresses three major problems in MRI: the induced gaps in 3D images, the constancy assumption of current optical flow algorithms and the existence of large non-linear movement. In this paper, we compare the performance of extracted kinetic features from the tumor regions under consideration of several 2-D or 3-D motion compensation parameters for the differential diagnosis of enhancing lesions in breast MRI. Based on several simulation results, we determined the optimal motion compensation parameters and showed that the proposed motion compensation algorithm can improve the correct lesion detection.