Disrupting the right pars opercularis with electrical stimulation frees the song: case report

Guillaume Herbet 1, 2 Gilles Lafargue 3 Fabien Almairac 4 Sylvie Moritz-Gasser 2 François Bonnetblanc 5, 6, 7 Hugues Duffau 2, 1, *
* Auteur correspondant
1 Neurochirurgie [Hôpital Gui de Chauliac]
2 INM - Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs
3 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies
4 Département de neurochirurgie (Hôpital Pasteur de Nice)
5 DEMAR - Artificial movement and gait restoration
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, CRISAM - Inria Sophia Antipolis - Méditerranée
6 IUF - Institut Universitaire de France
7 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
Abstract : The authors report the first case of a strikingly unusual speech impairment evoked by intraoperative electrostimulation in a 36-year-old right-handed patient, a well-trained singer, who underwent awake surgery for a right fronto-temporoinsular low-grade glioma. Functionally disrupting the pars opercularis of the right inferior frontal gyrus led the patient to automatically switch from a speaking to a singing mode of language production. Given the central role of the right pars opercularis in the inhibitory control network, the authors propose that this finding may be interpreted as possible evidence for a competitive and independent neurocognitive subnetwork devoted to the melodically intoned articulation of words (normal language-based vs singing-based) in subjects with high expertise. From a more clinical perspective, such data may have implications for awake neurosurgery, especially to preserve the quality of life for singers.
Keywords : right pars opercularis singing neural system speech inhibition inhibitory control electrical stimulation awake surgery functional neurosurgery language inhibition speaking aphasia cortex brain model
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01295785
Contributeur : Caps - Université de Bourgogne <>
Soumis le : jeudi 31 mars 2016 - 15:55:00
Dernière modification le : mardi 28 mai 2019 - 17:00:03

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UNIV-BOURGOGNE | CNRS | U1093 | DEMAR | LIRMM | INRIA | MIPS | BS | UNIV-MONTPELLIER | CAMIN

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Guillaume Herbet, Gilles Lafargue, Fabien Almairac, Sylvie Moritz-Gasser, François Bonnetblanc, et al.. Disrupting the right pars opercularis with electrical stimulation frees the song: case report. Journal of Neurosurgery, American Association of Neurological Surgeons, 2015, 123 (6), pp.1401-1404. ⟨10.3171/2014.12.JNS141829⟩. ⟨hal-01295785⟩

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