A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium

Laura Costas 1, 2, 3, * Brice H. Lambert 4 Brenda M. Birmann 5, 6 Kirsten B. Moysich 7 Anneclaire de Roos 8 Jonathan N. Hofmann 9 Dalsu Baris 9 Sophia S. Wang 10 Nicola J. Camp 11 Guido Tricot 12 Djordje Atanackovic 11 Paul Brennan 13 Pierluigi Cocco 14 Alexandra Nieters 15 Nikolaus Becker 16 Marc Maynadié 17, 18 Lenka Foretová 19 Paolo Boffetta 20 Anthony Staines 21 Elisabeth E. Brown 4 Silvia de Sanjosé 3, 1, 2
Abstract : Background: Female sex hormones are known to have immunomodulatory effects. Therefore, reproductive factors and exogenous hormone use could influence the risk of multiple myeloma in women. However, the role of hormonal factors in multiple myeloma etiology remains unclear because previous investigations were underpowered to detect modest associations. Methods: We conducted a pooled analysis of seven case-control studies included in the International Multiple Myeloma Consortium, with individual data on reproductive factors and exogenous hormone use from 1,072 female cases and 3,541 female controls. Study-specific odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression and pooled analyses were conducted using random effects meta-analyses. Results: Multiple myeloma was not associated with reproductive factors, including ever parous (OR=0.92, 95%CI=0.68-1.25), or with hormonal contraception use (OR=1.04, 95%CI=0.80-1.36). Postmenopausal hormone therapy users had non-significantly reduced risks of multiple myeloma compared with never users, but this association differed across centers (OR=0.65, 95%CI=0.37-1.15, I2=76.0%, p-heterogeneity= 0.01). Conclusions: These data do not support a role for reproductive factors or exogenous hormones in myelomagenesis. Impact: Incidence rates of multiple myeloma are higher in men than in women, and sex hormones could influence this pattern. Associations with reproductive factors and exogenous hormone use were inconclusive despite our large sample size, suggesting that female sex hormones may not play a significant role in multiple myeloma etiology.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01394129
Contributeur : Cep - Université de Bourgogne <>
Soumis le : mardi 8 novembre 2016 - 16:54:10
Dernière modification le : mercredi 4 décembre 2019 - 11:50:08

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Laura Costas, Brice H. Lambert, Brenda M. Birmann, Kirsten B. Moysich, Anneclaire de Roos, et al.. A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2015, 25 (1), pp.217 - 221. ⟨10.1158/1055-9965.EPI-15-0953⟩. ⟨hal-01394129⟩

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