Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties

Theodore Flack (1) , Thibaut Constantin (1) , Sylvain Penasse (1) , Jérôme Dejeu (1) , Béatrice Gennaro (1) , Muriel Jourdan (1) , Aurélien Laguerre (2) , Marc Pirrotta (2) , David Monchaud (2) , Nicolas Spinelli (1) , Eric Defrancq (1)

1 DCM - Département de Chimie Moléculaire
2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]

A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.

Mots clés: cyclodecapeptide; DNAzyme; G-quadruplexes; G-quartets; supramolecular chemistry; g-quadruplex structures; small molecules; dna; rna; ligands; water; insights; acid; chemistry; biology

Domaines: Chimie

Theodore Flack, Thibaut Constantin, Sylvain Penasse, Jérôme Dejeu, Béatrice Gennaro, et al.. Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties. Chemistry - A European Journal, 2016, 22 (5), pp.1760 - 1767. ⟨10.1002/chem.201504572⟩. ⟨hal-01400347⟩