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Article Dans Une Revue Chemistry - A European Journal Année : 2016

Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties

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Résumé

A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.

Dates et versions

hal-01400347 , version 1 (21-11-2016)

Identifiants

Citer

Theodore Flack, Thibaut Constantin, Sylvain Penasse, Jérôme Dejeu, Béatrice Gennaro, et al.. Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties. Chemistry - A European Journal, 2016, 22 (5), pp.1760 - 1767. ⟨10.1002/chem.201504572⟩. ⟨hal-01400347⟩
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