Near-Infrared-Emitting BODIPY-trisDOTA 111 In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations

Nicolas Maindron; Martin Ipuy; Claire Bernhard; Damien Lhenry; Mathieu Moreau; Sabin Carme; François Oudot; François Collin; François Vrigneaud; Peggy Provent; François Brunotte; Franck Denat; Christine Goze

doi:10.1002/chem.201602886

Article dans une revue

Near-Infrared-Emitting BODIPY-trisDOTA 111 In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations

Nicolas Maindron ¹ Martin Ipuy ¹ Claire Bernhard ¹ Damien Lhenry ¹ Mathieu Moreau ¹ Sabin Carme ¹ François Oudot ² François Collin ^{1, 2} François Vrigneaud ² Peggy Provent ³ François Brunotte ² Franck Denat ^{1, *} Christine Goze ^{1, *}

* Auteur correspondant

1 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]

2 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]

3 Oncodesign [Dijon]

Abstract : A new generation of monomolecular imaging probes (MOMIP) based on a distyryl-BODIPY (BODIPY= boron-dipyrromethene) coupled with three DOTA macrocycles has been prepared (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). The MOMIP presents good fluorescence properties and is very stable in serum. The bimodal probe was conjugated to trastuzumab, and an optical in vivo study showed high accumulation of the imaging agent at the tumor site. In-111 radiometallation of the bioconjugate was performed in high radiochemical yield, highlighting the potential of this new BODIPY-chelators derivative as a bimodal imaging probe.

Keywords : bimodal probes BODIPY DOTA MOMIP optical imaging guided surgery bodipy dyes cancer spect antibody platform antigen agents pet

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Chimie

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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01400355
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Soumis le : lundi 21 novembre 2016 - 19:13:28
Dernière modification le : jeudi 4 août 2022 - 17:08:40

Near-Infrared-Emitting BODIPY-trisDOTA 111 In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations

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Near-Infrared-Emitting BODIPY-trisDOTA 111 In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations

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