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Article dans une revue

Designing P-Chirogenic 1,2-Diphosphinobenzenes at Both P-Centers Using P(III)-Phosphinites

Abstract : A new enantiodivergent synthesis of P-chirogenic 1,2-diphosphinobenzenes (DP*B) bearing the chirality on one or both phosphorus centers is reported using aryne chemistry. The principle is based on successive reactions of 1,2-dibromobenzene with sec-phosphide boranes, then DABCO to remove the borane, and finally with chlorophosphines or P(III)-chirogenic phosphinites. The efficiency of this synthesis was demonstrated by the stereoselective preparation of (S,S)-1,2-bis(o-anisylphenylphosphino)benzene. A comparison of DIPAMP and homochiral DP*B ligands in asymmetric Rh- or Pd-catalyzed reactions was reported.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01403243
Contributeur : Icmub - Université de Bourgogne <>
Soumis le : vendredi 25 novembre 2016 - 15:44:52
Dernière modification le : vendredi 8 juin 2018 - 14:50:12

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Jérôme Bayardon, Yoann Rousselin, Sylvain Jugé. Designing P-Chirogenic 1,2-Diphosphinobenzenes at Both P-Centers Using P(III)-Phosphinites. Organic Letters, American Chemical Society, 2016, 18 (12), pp.2930 - 2933. ⟨10.1021/acs.orglett.6b01275⟩. ⟨hal-01403243⟩

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