Colorectal cancer care in elderly patients: Unsolved issues

Thomas Aparicio 1, * Frederic Pamoukdjian 2 Laurent Quero 3 Sylvain Manfredi 4, 5 Philippe Wind Elena Paillaud 6
* Auteur correspondant
1 Service de Gastro-entérologie [Avicenne]
2 Pôle Médecine Spécialisée et Vieillissement [Avicenne]
3 Service de cancérologie et radiothérapie [Saint-Louis]
4 LNC - Lipides - Nutrition - Cancer (U866)
5 Service d'Hépato-Gastro-Entérologie (CHU de Dijon)
6 Gériatrie - Henri Mondor - Unité de médecine gériatrique
Abstract : Colorectal cancers are common in elderly patients. However, cancer screening is poorly used after 75. Elderly patients form a heterogeneous population with specific characteristics. Standards of care cannot therefore be transposed from young to elderly patients. Tumour resection is frequently performed but adjuvant chemotherapy is rarely prescribed as there are no clearly established standards of care. In a metastatic setting, recent phase III studies have demonstrated that doublet front-line chemotherapy provided no survival benefit. Moreover, several studies have established the benefit of bevacizumab in association with chemotherapy. There is a lack of evidence for the efficacy of anti-epidermal growth factor antibodies in elderly patients. Geriatric assessments could help to select the adequate treatment strategy for individual patients. Geriatric oncology is now the challenge we have to face, and more specific trials are needed. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Keywords : Older patients Adjuvant-chemotherapy Adjuvant therapy Chemotherapy Geriatric oncology Radiotherapy Targeted therapy Comprehensive geriatric assessment Cetuximab plus irinotecan Mismatch repair phenotype Colon-cancer Rectal-cancer Pooled analysis 1st-line chemotherapy
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01407526
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 2 décembre 2016 - 12:21:56
Dernière modification le : mercredi 18 décembre 2019 - 15:48:02

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UNIV-BOURGOGNE | UNIV-PARIS7 | UNIV-PARIS13 | USPC | LNC-UMR866 | ENSBANA | AGROSUP-DIJON

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Thomas Aparicio, Frederic Pamoukdjian, Laurent Quero, Sylvain Manfredi, Philippe Wind, et al.. Colorectal cancer care in elderly patients: Unsolved issues. Digestive and Liver Disease, WB Saunders, 2016, 48 (10), pp.1112 - 1118. ⟨10.1016/j.dld.2016.05.011⟩. ⟨hal-01407526⟩

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