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Early Gastric Cancer: Trends in Incidence, Management, and Survival in a Well-Defined French Population

Nicolas Chapelle 1 Anne-Marie Bouvier 1 Sylvain Manfredi 1 Antoine Drouillard 1 Come Lepage 1 Jean Faivre 1 Valerie Jooste 1, * 
* Auteur correspondant
1 Registre Bourguignon des Cancers Digestifs
LNC - Lipides - Nutrition - Cancer (U866), CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
Abstract : Little is known about the epidemiology of early gastric cancer (EGC) in Western countries. The aim of this study was to analyze trends in the incidence, management, and survival of EGC in a well-defined population over a 30 year period. Data were obtained from the population-based cancer Registry of Burgundy (France). Incidence rates were calculated by sex, age, and 10 year period of diagnosis. Net survival rates were calculated and a multivariate relative survival analysis performed. EGC represented 6.7 % of gastric cancer diagnosed between 1982 and 2011. Age-standardized incidence rates were higher in men (0.79/100,000) than in women (0.40/100,000). Between the periods 1982-1991 and 2002-2011, it decreased from 0.97 to 0.53 per 100,000 in men and from 0.44 to 0.30 per 100,000 in women. Overall, 19 % of the tumors were limited to the mucosa, 69 % to the submucosa, and 15 % invaded lymph nodes. Node invasion and male sex were the only significant prognostic factors. Five-year net survival was 50 % in node-positive patients and 85 % in node-negative patients (p < 0.001). In multivariate analysis, the relative risk of death in men compared to women was 2.3 and was 10.4 in patients with positive nodes compared to patients with negative nodes. EGCs are rare in France. The prognosis is favorable, except for node-positive cancers, which may benefit from the recently developed adjuvant chemotherapy for gastric cancer.
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Soumis le : lundi 5 décembre 2016 - 11:18:07
Dernière modification le : samedi 21 mai 2022 - 03:47:23



Nicolas Chapelle, Anne-Marie Bouvier, Sylvain Manfredi, Antoine Drouillard, Come Lepage, et al.. Early Gastric Cancer: Trends in Incidence, Management, and Survival in a Well-Defined French Population. Annals of Surgical Oncology, Springer Verlag, 2016, 23 (11), pp.3677 - 3683. ⟨10.1245/s10434-016-5279-z⟩. ⟨hal-01408662⟩



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