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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Abstract : Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01427926
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 6 janvier 2017 - 10:39:22
Dernière modification le : mercredi 10 juin 2020 - 14:06:49

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Elísabet Alcocer-Gómez, Cristina Ulecia-Morón, Fabiola Marín-Aguilar, Tatyana Rybkina, Nieves Casas-Barquero, et al.. Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome. Molecular Neurobiology, Humana Press, 2016, 53 (7), pp.4874 - 4882. ⟨10.1007/s12035-015-9408-7⟩. ⟨hal-01427926⟩

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