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Article dans une revue
The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns
Abstract : Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02 mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined.
Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy. (C) 2016 Elsevier Inc. All rights reserved.
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01428023
Contributeur : Lnc - Université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : vendredi 6 janvier 2017 - 11:46:59
Dernière modification le : vendredi 8 juin 2018 - 14:50:12
Contributeur : Lnc - Université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : vendredi 6 janvier 2017 - 11:46:59
Dernière modification le : vendredi 8 juin 2018 - 14:50:12