Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns

Abstract : Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02 mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy. (C) 2016 Elsevier Inc. All rights reserved.
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01428023
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 6 janvier 2017 - 11:46:59
Dernière modification le : vendredi 8 juin 2018 - 14:50:12

Identifiants

Citation

Leila Hocine, Hafida Merzouk, Sid Ahmed Merzouk, Hafeda Ghorzi, Meriem Youbi, et al.. The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns. Pesticide Biochemistry and Physiology, Elsevier, 2016, 134, pp.49 - 54. ⟨10.1016/j.pestbp.2016.04.007⟩. ⟨hal-01428023⟩

Partager

Métriques

Consultations de la notice

198