Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Modulation of brain PUFA content in different experimental models of mice

Abstract : The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the different functions of the brain. Their brain levels depend on structures considered, on fatty acid dietary supply and the age of animals. To have a better overview of the different models available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals. Our results demonstrated that brain AA and DHA content is 1) structure-dependent; 2) strain-specific; 3) differently affected by dietary approaches when compared to genetic model of PUFA modulation; 4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse model of aging. From these experiments, we highlight the difficulty to compare results obtained in different mouse models, different strains, different brain regions and different ages.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : CSGA - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : lundi 9 janvier 2017 - 16:53:19
Dernière modification le : vendredi 20 mai 2022 - 09:06:35




Corinne Joffre, Stéphane Grégoire, Véronique de Smedt, Niyazi Acar, Lionel Brétillon, et al.. Modulation of brain PUFA content in different experimental models of mice. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016, 114, pp.1 - 10. ⟨10.1016/j.plefa.2016.09.003⟩. ⟨hal-01430319⟩



Consultations de la notice