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In vitro toxicity assessment of extracts derived from sol–gel coatings on polycarbonate intended to be used in food contact applications

Isabelle Séverin 1, * Krystelle Lionti 2 Laurence Dahbi 1 Catherine Loriot 3 Bérangère Toury 4 Marie-Christine Chagnon 1 
* Auteur correspondant
1 Derttech Packtox
LNC - Lipides - Nutrition - Cancer (U866), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
Abstract : Polycarbonate is a widely used polymer in food contact applications all around the world. However, due to the potential release of Bisphenol A (BPA) during repeated washing cycles, its use becomes compromised as BPA is known for being an endocrine disruptor for rodents. In order to tackle this issue, sol-gel coatings based on organoalkoxysiloxane were developed on PC, to act as a physical barrier. To this end, two sol-gel systems based on tetraethylorthosilicate (TEOS), methyltriethoxysilane (MTES) and 3-glycidyloxypropyltriethoxysilane (GPTES), three common sol-gel precursors, were prepared. The coatings derived from the latter two systems were then studied with regards to their potential toxicity in vitro. Migration tests were performed in food simulants, and the maximal migration was obtained in ethanol 10% (v/v) for one system and in isooctane for the other one. In vitro genotoxicity was assessed with the Ames test (OECD 471) and the micronucleus assay (OECD 487), and no genotoxic effect was observed. Moreover, the estrogenic activity of the extracts was studied with a transcriptional activation assay using transient transfection in human cells; none of the extracts was found estrogenic. These negative in vitro results are highly promising for the future use of these new barrier coating formulations onto food contact materials. (C) 2016 Elsevier Ltd. All rights reserved.
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Contributeur : LNC - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : mardi 13 avril 2021 - 11:29:00
Dernière modification le : lundi 21 novembre 2022 - 03:52:53
Archivage à long terme le : : mercredi 14 juillet 2021 - 18:22:29


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Isabelle Séverin, Krystelle Lionti, Laurence Dahbi, Catherine Loriot, Bérangère Toury, et al.. In vitro toxicity assessment of extracts derived from sol–gel coatings on polycarbonate intended to be used in food contact applications. Food and Chemical Toxicology, 2016, 93, pp.51 - 57. ⟨10.1016/j.fct.2016.04.025⟩. ⟨hal-01434899⟩



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