Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

Abstract : Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (lifestyle) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5'-lipoxygenase (5'-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p < 0.0001), while AA genotype. does so 1.79-fold (p < 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age. (C) 2016 Elsevier B.V. All rights reserved.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01435071
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 13 janvier 2017 - 15:43:32
Dernière modification le : mercredi 19 février 2020 - 13:10:05

Identifiants

Citation

Omar Šerý, Lýdia Hlinecká, Jana Povová, Ondřej Bonczek, Tomáš Zeman, et al.. Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. Journal of the Neurological Sciences, Elsevier, 2016, 362, pp.27 - 32. ⟨10.1016/j.jns.2016.01.022⟩. ⟨hal-01435071⟩

Partager

Métriques

Consultations de la notice

148