Positive impact of autophagy in human breast cancer cells on local immunosurveillance. - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue OncoImmunology Année : 2016

Positive impact of autophagy in human breast cancer cells on local immunosurveillance.

Résumé

In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B(+) puncta within malignant cells positively correlate with the intratumoral abundance of CD8(+) cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3(+) regulatory T cells and CD68(+) tumor-associated macrophages, resulting in an improvement of CD8(+)/FOXP(+) or CD8(+)/CD68(+) ratios.

Domaines

Cancer Immunologie

Dates et versions

hal-01438357 , version 1 (17-01-2017)

Identifiants

Citer

Sylvain Ladoire, David Enot, Laura Senovilla, Marie Chaix, Laurence Zitvogel, et al.. Positive impact of autophagy in human breast cancer cells on local immunosurveillance.. OncoImmunology, 2016, 5 (6), pp.e1174801. ⟨10.1080/2162402X.2016.1174801⟩. ⟨hal-01438357⟩
175 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More