Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.

Résumé : It has recently been shown that an allele in the glucokinase regulatory protein (GCKR) gene was associated with increased liver fat content in obese children. In this study, we set out to determine whether GCKR rs1260326 polymorphism was associated with liver fat content in patients with type 2 diabetes. Three hundred and eight patients with type 2 diabetes were included in this study. Liver fat content was evaluated using 1H-MR spectroscopy. In our population, carriers of the rs1260326 minor T allele had a higher liver fat content than did carriers of the C allele homozygote (12.4 +/- A 9.6 vs. 10.3 +/- A 9.1 %, p = 0.03). The number of patients with steatosis was significantly higher in minor T allele carriers than in C allele homozygote carriers (70.7 vs. 55.4 %; p = 0.008). In multivariate analysis, the predictive variables for steatosis were BMI [odds ratio (OR) 1.08; 95 % confidence interval (CI) 1.03-1.13; p = 0.002], statin therapy (yes) [OR 0.54; 95 % CI 0.31-0.94; p = 0.03], metformin therapy (yes) [OR 2.67; 95 % CI 1.50-4.75; p < 0.001], and rs1260326 GCKR polymorphism (TT+CT) [OR 1.99; 95 % CI 1.14-3.47; p = 0.01]. This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism independent of BMI, triglyceride levels, and age.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01441868
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 20 janvier 2017 - 11:38:23
Dernière modification le : jeudi 28 mai 2020 - 03:32:56

Licence


Distributed under a Creative Commons Paternité - Partage selon les Conditions Initiales 4.0 International License

Identifiants

Citation

Jean-Michel Petit, David Masson, Boris Guiu, Fabien Rollot, Laurence Duvillard, et al.. GCKR polymorphism influences liver fat content in patients with type 2 diabetes.. Acta Diabetologica, Springer Verlag, 2016, 53 (2), pp.237-42. ⟨10.1007/s00592-015-0766-4⟩. ⟨hal-01441868⟩

Partager

Métriques

Consultations de la notice

144