M. W. Schwartz, S. C. Woods, D. Porte, J. Seeley, R. J. Baskin et al., Central nervous system control of food intake, Nature, vol.404, pp.661-671, 2000.

X. Fioramonti, S. Contie, Z. Song, V. H. Routh, A. Lorsignol et al., Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro?opio melanocortin networks?, Diabetes, vol.56, pp.1219-1227, 2007.

Z. Song, B. E. Levin, J. J. Mcardle, N. Bakhos, and V. H. Routh, Convergence of pre? and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus, vol.50, pp.2673-2681, 2001.

Y. Oomura, T. Ono, H. Ooyama, and M. J. Wayner, Glucose and osmosensitive neurones of the rat hypothalamus, Nature, vol.222, pp.282-284, 1969.

Y. Oomura, H. Ooyama, M. Sugimori, T. Nakamura, and Y. Yamada, Glucose inhibition of the glucose?sensitive neurone in the rat lateral hypothalamus, Nature, vol.247, pp.284-286, 1974.

T. K. Lam, R. Gutierrez?juarez, A. Pocai, and L. Rossetti, Regulation of blood glucose by hypothalamic pyruvate metabolism, Science, vol.309, pp.943-947, 2005.

C. Leloup, C. Magnan, A. Benani, E. Bonnet, T. Alquier et al., Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing, Diabetes, vol.55, pp.2084-2090, 2006.

L. Carneiro, C. Allard, C. Guissard, X. Fioramonti, C. Tourrel?cuzin et al.,

, Antioxid Redox Signal, vol.17, pp.433-444, 2012.

Z. B. Andrews, Z. W. Liu, N. Walllingford, D. M. Erion, E. Borok et al., UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals, Nature, vol.454, pp.846-851, 2008.

C. Toda, J. D. Kim, D. Impellizzeri, S. Cuzzocrea, Z. W. Liu et al., Transient receptor potential canonical 3 (trpc3) Figure 4: MBH TRPC3 channels ar e r equir ed for brain glucose det ect ion. A. Food int ake in response t o int racerebrovent ricular ( I CV) infusion of glucose or sucrose ( lat eral vent ricule, 0.125 µg in 2 µl infused in 5 m in) in 18h fast ed/ TRPC3 WT ( Sucrose: n= 6; Glucose: n= 5) and TRPC3 KO m ice ( Sucrose: n= 6; Glucose: n= 6) . B. Food intake in response t o int raper it oneal infusion of glucose ( 2 g kg) or NaCl ( 0.9 % ) in 18h, UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell ce document : Chrétien, 2017.

, delt a insulin secret ion vs. t = 0; C right below) in response t o an int racarot id glucose inj ect ion ( 25 m g kg) in TRPC3 WT ( n= 8) and KO ( n= 13) m ice. D. Experim ent al prot ocol ( D left ) , blood glucose ( D right above) or plasm a insulin ( delt a insulin secret ion vs. t = 08) . * : p< 0.05, * * p < 0.01 vs. WT or Vehicle, Two/ way ANOVA + bonfer oni post / hoc t est, Experim ent al prot ocol ( C left ) , blood glucose ( C right t op) and plasm a insulin

C. Chrétien, C. Fenech, F. Liénard, S. Grall, C. Chevalier et al., , 2017.

C. Chrétien, C. Fenech, F. Liénard, S. Grall, C. Chevalier et al., , 2017.