C. Cargoqol, Center for Epidemiologic Studies-Depression Scale questionnaire; CRA: Clinical Research Assistant; EQ-5D: European Quality of life ? 5 dimensions questionnaire; HADS: Hospital Anxiety and Depression Scale; HRQoL: Healthrelated quality of life; ICER: Incremental Cost-Effectiveness Ratio; LASA: Linear Analogue Scale Assessment quality of life questionnaire; MCID: Minimal Clinically Important Difference; MMSE: Mini Mental State Examination; MOS SF-36: Medical Outcome Study Short Form-36 items Quality-adjusted life year; RSQ: Relationship Scales Questionnaire, SD: Standard deviation; SF-6D: Short Form ? 6 dimensions

M. Demarchi, Isabelle Desmoulins (Dr.), Oncology Department, Centre de Lutte Contre le Cancer Georges François Leclerc

J. Fraisse, France; Véronique Lorgis (Dr.), Oncology Department, Centre de Lutte Contre le Cancer Georges François Leclerc Oncology and Radiotherapy Department, Centre de Lutte Contre le Cancer Georges François Leclerc, Neurology Department Geriatric Department Geriatric Department Oncology and Radiotherapy Department Neurology Department Surgery Department Geriatric Department Psychiatry Department Oncology Department

C. Goillot and P. Mormiche, Les enquêtes handicap incapacité et dépendance de, Insee Resultats, p.22, 1998.

I. Fonareva and B. Oken, Physiological and functional consequences of caregiving for relatives with dementia, International Psychogeriatrics, vol.24, issue.05, pp.725-772, 2014.
DOI : 10.1097/01.JGP.0000225109.85406.89

T. Jowsey, I. Mcrae, J. Gillespie, M. Banfield, and Y. L. , Time to care? Health of informal older carers and time spent on health related activities: an Australian survey, BMC Public Health, vol.1, issue.1, p.374, 2013.
DOI : 10.1111/j.1440-1797.2005.00409.x

J. Novella, Prévenir le syndrôme de l'épuisement de l'aidant du sujet âgé dépendant pour un meilleurmaintien à domicile, Revue Geriatr, vol.26, pp.143-50, 2001.

C. Faure, Vivre auprès d'un proche très malade, 1998.

M. Cameron, L. Massuch, and D. Wishart, Recommendations for effective caregiver interventions, p.6, 2008.

E. Mestheneos and J. Triantafillou, Supporting family carers of older people in Europe, 2005.

L. Etters, D. Goodall, and B. Harrison, Caregiver burden among dementia patient caregivers: A review of the literature, Journal of the American Academy of Nurse Practitioners, vol.26, issue.2, pp.423-431, 2008.
DOI : 10.1111/j.1745-7599.2008.00342.x

N. Carpentier, Reconnaissance et respect: vers un meilleur arrimage entre intervenants et proches aidants, 2010.

N. Carpentier, P. Bernard, A. Grenier, and N. Guberman, Using the life course perspective to study the entry into the illness trajectory: The perspective of caregivers of people with Alzheimer's disease, Social Science & Medicine, vol.70, issue.10, pp.1501-1509, 2010.
DOI : 10.1016/j.socscimed.2009.12.038

F. Ducharme, L. Beaudet, A. Legault, M. Kergoat, L. Levesque et al., Development of an Intervention Program for Alzheimer's Family Caregivers Following Diagnostic Disclosure, Clinical Nursing Research, vol.18, issue.1, pp.44-67, 2009.
DOI : 10.1177/1054773808330093

F. Ducharme, L. Levesque, L. Lachance, M. Kergoat, and R. Coulombe, Challenges associated with transition to caregiver role following diagnostic disclosure of Alzheimer disease: A descriptive study, International Journal of Nursing Studies, vol.48, issue.9, pp.1109-1128, 2011.
DOI : 10.1016/j.ijnurstu.2011.02.011

F. Ducharme, L. Levesque, L. Lachance, M. Kergoat, A. Legault et al., "Learning to Become a Family Caregiver" Efficacy of an Intervention Program for Caregivers Following Diagnosis of Dementia in a Relative, The Gerontologist, vol.51, issue.4, pp.484-94, 2011.
DOI : 10.1093/geront/gnr014

J. Guay, The social worker and family caregivers, Sant?? mentale au Qu??bec, vol.7, issue.1, pp.21-28, 1982.
DOI : 10.7202/030120ar

M. Hoehn and M. Yahr, Parkinsonism: onset, progression, and mortality, Neurology, vol.17, issue.5, pp.427-469, 1967.
DOI : 10.1212/WNL.17.5.427

D. Locke, Validation of single-item linear analog scale assessment of quality of life in neuro-oncology patients NIHPA Manuscripts, pp.628-666, 2007.

R. Jaeschke, J. Singer, and G. Guyatt, Measurement of health status, Controlled Clinical Trials, vol.10, issue.4, pp.407-422, 1989.
DOI : 10.1016/0197-2456(89)90005-6

C. Anderson, S. Laubscher, and R. Burns, Validation of the Short Form 36 (SF-36) Health Survey Questionnaire Among Stroke Patients, Stroke, vol.27, issue.10, pp.1812-1818, 1996.
DOI : 10.1161/01.STR.27.10.1812

J. Brazier, R. Harper, N. Jones, O. Cathain, A. Thomas et al., Validating the SF-36 health survey questionnaire: new outcome measure for primary care., BMJ, vol.305, issue.6846, pp.160-164, 1992.
DOI : 10.1136/bmj.305.6846.160

A. Garratt, L. Schmidt, A. Mackintosh, and R. Fitzpatrick, Quality of life measurement: bibliographic study of patient assessed health outcome measures, BMJ, vol.324, issue.7351, p.1417, 2002.
DOI : 10.1136/bmj.324.7351.1417

C. Mchorney, W. Jr, J. Lu, J. Sherbourne, and C. , The MOS 36-Item Short-Form Health Survey (SF-36), Medical Care, vol.31, issue.3, pp.40-66, 1994.
DOI : 10.1097/00005650-199303000-00006

C. Mchorney, W. Jr, J. Raczek, and A. , The MOS 36-Item Short-Form Health Survey (SF-36), Medical Care, vol.31, issue.3, pp.247-63, 1993.
DOI : 10.1097/00005650-199303000-00006

J. Ware, M. Kosinski, and S. Keller, SF-12®: how to score the SF-12® Physical and Mental Health Summary Scales, 1995.

J. Ware and C. Sherbourne, The MOS 36-item short-form health survey (SF-36

A. Leplege, E. Ecosse, A. Verdier, and T. Perneger, The French SF-36 Health Survey, Journal of Clinical Epidemiology, vol.51, issue.11, pp.1013-1036, 1998.
DOI : 10.1016/S0895-4356(98)00093-6

A. Leplege, M. Mesbah, and P. Marquis, Preliminary analysis of the psychometric properties of the French version of an international questionnaire measuring the quality of life: the MOS SF-36 (version 1.1), Rev Epidemiol Sante Publique, vol.43, issue.4, pp.371-380, 1995.

P. Minaya, K. Baumstarck, J. Berbis, A. Goncalves, F. Barlesi et al., The CareGiver Oncology Quality of Life questionnaire (CarGOQoL): Development and validation of an instrument to measure the quality of life of the caregivers of patients with cancer, European Journal of Cancer, vol.48, issue.6, pp.904-915, 2012.
DOI : 10.1016/j.ejca.2011.09.010

J. Lepine, M. Godchau, and P. Brun, ANXIETY AND DEPRESSION IN INPATIENTS, The Lancet, vol.326, issue.8469-8470, pp.8469-701425, 1985.
DOI : 10.1016/S0140-6736(85)92589-9

J. Lepine, M. Godchau, P. Brun, and T. Lemperiere, Evaluation of anxiety and depression among patients hospitalized on an internal medicine service

D. Razavi, N. Delvaux, C. Farvacques, and E. Robaye, Validation de la version française du HADs dans une population de patients cancéreux hospitalisés, Rev Psychol Appl, vol.39, issue.4, pp.285-307, 1989.

X. Borteyrou, D. Truchot, and N. Rascle, Le stress chez le personnel travaillant en oncologie: une tentative de classification des stratégies de coping

N. Rascle, M. Bruchon-schweitzer, and I. Sarason, SHORT FORM OF SARASON'S SOCIAL SUPPORT QUESTIONNAIRE: FRENCH ADAPTATION AND VALIDATION, Psychological Reports, vol.54, issue.5, pp.195-202, 2005.
DOI : 10.2466/PR0.97.5.195-202

R. Hebert, G. Bravo, and D. Girouard, Fid??lit?? de la traduction fran??aise de trois instruments d'??valuation des aidants naturels de malades d??ments, Canadian Journal on Aging / La Revue canadienne du vieillissement, vol.29, issue.03, pp.324-361, 1993.
DOI : 10.1037/0882-7974.2.3.225

I. Sarason, M. Henry, R. Basham, and B. Sarason, Assessing social support: The Social Support Questionnaire., Journal of Personality and Social Psychology, vol.44, issue.1, pp.127-166, 1983.
DOI : 10.1037/0022-3514.44.1.127
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.458.9485

S. Zarit, K. Reever, and J. Bach-peterson, Relatives of the Impaired Elderly: Correlates of Feelings of Burden, The Gerontologist, vol.20, issue.6, pp.649-55, 1980.
DOI : 10.1093/geront/20.6.649

R. Launois, A. Vergnenégre, and B. Garrigues, Costs, costs and more costs: which one should we use? Bull Cancer, pp.946-54, 2003.

S. Whitehead and S. Ali, Health outcomes in economic evaluation: the QALY and utilities, British Medical Bulletin, vol.96, issue.1, pp.5-21, 2010.
DOI : 10.1093/bmb/ldq033

J. Brazier, T. Usherwood, R. Harper, and K. Thomas, Deriving a Preference-Based Single Index from the UK SF-36 Health Survey, Journal of Clinical Epidemiology, vol.51, issue.11, pp.1115-1143, 1998.
DOI : 10.1016/S0895-4356(98)00103-6

J. Brazier and J. Roberts, The Estimation of a Preference-Based Measure of Health From the SF-12, Medical Care, vol.42, issue.9, pp.851-860, 2004.
DOI : 10.1097/01.mlr.0000135827.18610.0d

R. Führer and F. Rouillon, The French version of CES-D: description and translation of the self-report scale, Psychiatrie Psychobiol, vol.4, pp.163-169, 1989.

D. Griffin and K. Bartholomew, Metaphysics of measurement: the case of adult attachment Advances in personal relationships: attachment processes in adulthood, 1994.

G. Taylor, D. Ryan, and R. Bagby, Toward the Development of a New Self-Report Alexithymia Scale, Psychotherapy and Psychosomatics, vol.44, issue.4, pp.191-200, 1985.
DOI : 10.1159/000287912

C. Given, B. Given, M. Stommel, C. Collins, S. King et al., The caregiver reaction assessment (CRA) for caregivers to persons with chronic physical and mental impairments, Research in Nursing & Health, vol.20, issue.4, pp.271-83, 1992.
DOI : 10.1002/nur.4770150406

R. Development and C. Team, R: A language and environment for statistical computing Vienna: R Foundation for Statistical Computing, 2010.

D. Demets and K. Lan, Interim analysis: The alpha spending function approach, Statistics in Medicine, vol.13, issue.13-14, pp.13-141341, 1994.
DOI : 10.1002/sim.4780131308

F. Bonnetain, L. Dahan, E. Maillard, M. Ychou, E. Mitry et al., Time until definitive quality of life score deterioration as a means of longitudinal analysis for treatment trials in patients with metastatic pancreatic adenocarcinoma, European Journal of Cancer, vol.46, issue.15, pp.2753-62, 2010.
DOI : 10.1016/j.ejca.2010.07.023

Z. Hamidou, T. Dabakuyo, M. Mercier, J. Fraisse, S. Causeret et al., Time to Deterioration in Quality of Life Score as a Modality of Longitudinal Analysis in Patients with Breast Cancer, The Oncologist, vol.16, issue.10, pp.1458-68, 2011.
DOI : 10.1634/theoncologist.2011-0085
URL : https://hal.archives-ouvertes.fr/hal-00687536