Circulating tumor DNA and circulating tumor cells as predictor of outcome in the PRODIGE14-ACCORD21-METHEP2 phase II trial

Abstract : Background: We prospectively detected circulating tumor DNA (ctDNA) and circulating tumor cells (CTC) levels in patients (pts) included in the PRODIGE14-ACCORD21-METHEP2 randomized phase II trial. Methods: The trial enrolled colorectal cancer pts with potentially resectable liver metastases & no prior treatment; the primary endpoint was the rate of R0/R1 liver metastases resection achieved by 1st line regimen (targeted therapies & bi- vs tri-chemotherapy; Ychou, ASCO 2016). Blood samples were collected at inclusion, after 1 month of therapy and before any liver metastases surgery. CTCs (CellSearch) & ctDNA (ddPCR, BioRad) were detected in an experienced laboratory (Inst. Curie). Results: 153 pts had at least one blood analysis. High CTC count (≥3 CTC/7.5ml) was detected in 25/132 pts (19%) at baseline and associated with synchronous...
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Communication dans un congrès
the 41st ESMO Congress (ESMO 2016), Oct 2016, Copenhague, Denmark. Annals of oncology, 27 (suppl_6), pp.456O, 2016, Abstract Book of the 41st ESMO Congress (ESMO 2016). 〈https://academic.oup.com/annonc/article-abstract/27/suppl_6/456O/2799195/Circulating-tumor-DNA-and-circulating-tumor-cells?redirectedFrom=fulltext〉. 〈10.1093/annonc/mdw370.5〉
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01490996
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : jeudi 16 mars 2017 - 11:26:14
Dernière modification le : mercredi 5 septembre 2018 - 15:32:02

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François-Clément Bidard, M. Ychou, J. Madic, A. Saliou, O. Bouche, et al.. Circulating tumor DNA and circulating tumor cells as predictor of outcome in the PRODIGE14-ACCORD21-METHEP2 phase II trial. the 41st ESMO Congress (ESMO 2016), Oct 2016, Copenhague, Denmark. Annals of oncology, 27 (suppl_6), pp.456O, 2016, Abstract Book of the 41st ESMO Congress (ESMO 2016). 〈https://academic.oup.com/annonc/article-abstract/27/suppl_6/456O/2799195/Circulating-tumor-DNA-and-circulating-tumor-cells?redirectedFrom=fulltext〉. 〈10.1093/annonc/mdw370.5〉. 〈hal-01490996〉

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