Reinforced cyclam derivatives functionalized on the bridging unit

Nicolas Sok 1, * Isabelle Baglin 2 Yoann Rousselin 2 Frederic Boschetti 3 Claire Bernhard 2 Christine Goze 2 Franck Denat 2
* Auteur correspondant
1 PAM - Procédés Alimentaires et Microbiologiques
2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
3 CheMatech - Macrocycle Design Technologies
Abstract : A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
Keywords : Continuous symmetry measures Coordination chemistry Bifunctional chelator Copper(ii) complexes Radiometals Stability Polyhedra Therapy
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01492972
Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : vendredi 8 juin 2018 - 14:50:22

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UNIV-BOURGOGNE | CNRS | PAM | INC-CNRS | ICMUB | AGROSUP-DIJON | AGROSUP-PAM

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Nicolas Sok, Isabelle Baglin, Yoann Rousselin, Frederic Boschetti, Claire Bernhard, et al.. Reinforced cyclam derivatives functionalized on the bridging unit. New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5829 - 5834. ⟨10.1039/c5nj03488d⟩. ⟨hal-01492972⟩

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