Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Reinforced cyclam derivatives functionalized on the bridging unit

Abstract : A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01492972
Contributeur : PAM - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : lundi 21 novembre 2022 - 03:53:22

Identifiants

Citation

Nicolas Sok, Isabelle Baglin, Yoann Rousselin, Frederic Boschetti, Claire Bernhard, et al.. Reinforced cyclam derivatives functionalized on the bridging unit. New Journal of Chemistry, 2016, 40 (7), pp.5829 - 5834. ⟨10.1039/c5nj03488d⟩. ⟨hal-01492972⟩

Partager

Métriques

Consultations de la notice

42