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Article dans une revue
Reinforced cyclam derivatives functionalized on the bridging unit
Abstract : A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01492972
Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : mardi 8 décembre 2020 - 10:00:05
Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : mardi 8 décembre 2020 - 10:00:05