Reinforced cyclam derivatives functionalized on the bridging unit

Abstract : A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
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Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : lundi 16 décembre 2019 - 11:22:02



Nicolas Sok, Isabelle Baglin, Yoann Rousselin, Frederic Boschetti, Claire Bernhard, et al.. Reinforced cyclam derivatives functionalized on the bridging unit. New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5829 - 5834. ⟨10.1039/c5nj03488d⟩. ⟨hal-01492972⟩



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