Reinforced cyclam derivatives functionalized on the bridging unit

Nicolas Sok; Isabelle Baglin; Yoann Rousselin; Frederic Boschetti; Claire Bernhard; Christine Goze; Franck Denat

Reinforced cyclam derivatives functionalized on the bridging unit

Nicolas Sok ^{1, *} Isabelle Baglin ² Yoann Rousselin ² Frederic Boschetti ³ Claire Bernhard ² Christine Goze ² Franck Denat ²

* Auteur correspondant

1 PAM - Procédés Alimentaires et Microbiologiques

2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]

3 CheMatech - Macrocycle Design Technologies

Abstract : A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.

Keywords : Continuous symmetry measures Coordination chemistry Bifunctional chelator Copper(ii) complexes Radiometals Stability Polyhedra Therapy

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Ingénierie des aliments

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01492972
Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 20 mars 2017 - 16:57:01
Dernière modification le : vendredi 8 juin 2018 - 14:50:22

Reinforced cyclam derivatives functionalized on the bridging unit

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Reinforced cyclam derivatives functionalized on the bridging unit

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