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Article Dans Une Revue New Journal of Chemistry Année : 2016

Reinforced cyclam derivatives functionalized on the bridging unit

Résumé

A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
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Dates et versions

hal-01492972 , version 1 (20-03-2017)

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Nicolas Sok, Isabelle Baglin, Yoann Rousselin, Frederic Boschetti, Claire Bernhard, et al.. Reinforced cyclam derivatives functionalized on the bridging unit. New Journal of Chemistry, 2016, 40 (7), pp.5829 - 5834. ⟨10.1039/c5nj03488d⟩. ⟨hal-01492972⟩
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