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Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

Kwang-Zin Lee 1, 2, * Matthieu Lestradet 3, 1 Catherine Socha 1 Stefanie Schirmeier 1, 4 Antonin Schmitz 5 Caroline Spenlé 6, 7, 8, 9 Olivier Lefebvre 6, 7, 8, 9 Céline Keime 10 Wennida M. Yamba 1 Richard Bou Aoun 1, 11 Samuel Liegeois 1 Yannick Schwab 10 Patricia Simon-Assmann 6, 7, 8, 9 Frédéric Dalle 12, 5 Dominique Ferrandon 1, *
* Auteur correspondant
1 RIDI - UPR 9002 - Réponse immunitaire et developpement chez les insectes
2 Institut für Insektenbiotechnologie [Justus-Liebig-Universität Gießen]
3 INMG - Institut NeuroMyoGène
4 Institut für Neuro- und Verhaltensbiologie [Münster]
5 Agroécologie [Dijon]
6 Immuno-Rhumatologie Moléculaire
7 UNISTRA - Université de Strasbourg
8 FMTS - Fédération de Médecine Translationnelle de Strasbourg
9 Centre de recherche du médicament Medalis - Drug Discovery Center [LabEx]
10 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
11 CEED - Defymed : Centre Européen Étude du Diabète
12 PAM - Procédés Alimentaires et Microbiologiques
Abstract : Besides digesting nutrients, the gut protects the host against invasion by pathogens. Enterocytes may be subjected to damage by both microbial and host defensive responses, causing their death. Here, we report a rapid epithelial response that alleviates infection stress and protects the enterocytes from the action of microbial virulence factors. Intestinal epithelia exposed to hemolysin, a pore-forming toxin secreted by Serratia marcescens, undergo an evolutionarily conserved process of thinning followed by the recovery of their initial thickness within a few hours. In response to hemolysin attack, Drosophila melanogaster enterocytes extrude most of their apical cytoplasm, including damaged organelles such as mitochondria, yet do not lyse. We identify two secreted peptides, the expression of which requires CyclinJ, that mediate the recovery phase in which enterocytes regain their original shape and volume. Epithelial thinning and recovery constitute a fast and efficient response to intestinal infections, with pore-forming toxins acting as alarm signals.
Keywords : Drosophila cyclin j Mitochondrial extrusion Bacterial-infection Serratia-marcescens Disease tolerance Virulence factors Defense strategy Plasma-membrane Lipid droplets Oral infection
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01507264
Contributeur : Pam - Université de Bourgogne <>
Soumis le : mercredi 12 avril 2017 - 17:58:33
Dernière modification le : mardi 30 mars 2021 - 03:46:45

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UNIV-BOURGOGNE | CNRS | IGBMC | INRA | PAM | AGROECOLOGIE | UNIV-LYON1 | SITE-ALSACE | UDL | INRAE

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Kwang-Zin Lee, Matthieu Lestradet, Catherine Socha, Stefanie Schirmeier, Antonin Schmitz, et al.. Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. Cell Host and Microbe, Elsevier, 2016, 20 (6), pp.716 - 730. ⟨10.1016/j.chom.2016.10.010⟩. ⟨hal-01507264⟩

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