Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

Abstract : Besides digesting nutrients, the gut protects the host against invasion by pathogens. Enterocytes may be subjected to damage by both microbial and host defensive responses, causing their death. Here, we report a rapid epithelial response that alleviates infection stress and protects the enterocytes from the action of microbial virulence factors. Intestinal epithelia exposed to hemolysin, a pore-forming toxin secreted by Serratia marcescens, undergo an evolutionarily conserved process of thinning followed by the recovery of their initial thickness within a few hours. In response to hemolysin attack, Drosophila melanogaster enterocytes extrude most of their apical cytoplasm, including damaged organelles such as mitochondria, yet do not lyse. We identify two secreted peptides, the expression of which requires CyclinJ, that mediate the recovery phase in which enterocytes regain their original shape and volume. Epithelial thinning and recovery constitute a fast and efficient response to intestinal infections, with pore-forming toxins acting as alarm signals.
Type de document :
Article dans une revue
Cell Host and Microbe, Elsevier, 2016, 20 (6), pp.716 - 730. 〈10.1016/j.chom.2016.10.010〉
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01507264
Contributeur : Pam - Université de Bourgogne <>
Soumis le : mercredi 12 avril 2017 - 17:58:33
Dernière modification le : vendredi 22 juin 2018 - 13:08:04

Identifiants

Citation

Kwang-Zin Lee, Matthieu Lestradet, Catherine Socha, Stefanie Schirmeier, Antonin Schmitz, et al.. Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. Cell Host and Microbe, Elsevier, 2016, 20 (6), pp.716 - 730. 〈10.1016/j.chom.2016.10.010〉. 〈hal-01507264〉

Partager

Métriques

Consultations de la notice

147