Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging

Nicolas Sok; Maria Nikolantonaki; Stéphane Guyot; Thanh Dat Nguyen; Anne-Sophie Viaux; Franck Bagala; Yoann Rousselin; Florence Husson; Régis Gougeon; Rémi Saurel

doi:10.1016/j.snb.2016.09.171

Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging

Nicolas Sok ^{1, *} Maria Nikolantonaki ¹ Stéphane Guyot ¹ Thanh Dat Nguyen ¹ Anne-Sophie Viaux ¹ Franck Bagala ¹ Yoann Rousselin ² Florence Husson ¹ Régis Gougeon ¹ Rémi Saurel ¹

* Auteur correspondant

1 PAM - Procédés Alimentaires et Microbiologiques

2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]

Abstract : We report herein an efficient synthesis of news naphtalimide-based fluorescent derivatives functionalized with an a,(3-unsaturated carbonyl group. Probes were synthesized from reaction of an amino-naphtalimide precursor with maleic anhydride. Photophysical study of fluorescent probes and cells labelling were performed, and showed that the reactive derivatives exhibit rich turn on fluorescence properties in presence of different biological thiol (Glutathione and Cysteine) making these systems a very promising way for thiol bioimaging.

Keywords : 1 4-addition Thiol probes Biological thiols Michael's addition Turn-on fluorescence Bioimaging Homocysteine Glutathione Ketones

Type de document :

Article dans une revue

Sensors and Actuators B: Chemical, Elsevier, 2017, 242, pp.865 - 871. 〈10.1016/j.snb.2016.09.171〉

Domaine :

Sciences du Vivant [q-bio] / Ingénierie des aliments

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01509840
Contributeur : Pam - Université de Bourgogne <>
Soumis le : mardi 18 avril 2017 - 15:40:39
Dernière modification le : vendredi 8 juin 2018 - 14:50:22

Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging

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Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging

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