Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging

Nicolas Sok 1, * Maria Nikolantonaki 1 Stéphane Guyot 1 Thanh Dat Nguyen 1 Anne-Sophie Viaux 1 Franck Bagala 1 Yoann Rousselin 2 Florence Husson 1 Régis Gougeon 1 Rémi Saurel 1
* Auteur correspondant
1 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
Abstract : We report herein an efficient synthesis of news naphtalimide-based fluorescent derivatives functionalized with an a,(3-unsaturated carbonyl group. Probes were synthesized from reaction of an amino-naphtalimide precursor with maleic anhydride. Photophysical study of fluorescent probes and cells labelling were performed, and showed that the reactive derivatives exhibit rich turn on fluorescence properties in presence of different biological thiol (Glutathione and Cysteine) making these systems a very promising way for thiol bioimaging.
Keywords : Ketones Glutathione Homocysteine Bioimaging Turn-on fluorescence Michael's addition Biological thiols Thiol probes 4-addition 1
Type de document :
Article dans une revue
Sensors and Actuators B: Chemical, Elsevier, 2017, 242, pp.865 - 871. 〈10.1016/j.snb.2016.09.171〉
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Contributeur : Pam - Université de Bourgogne <>
Soumis le : mardi 18 avril 2017 - 15:40:39
Dernière modification le : jeudi 11 octobre 2018 - 11:59:41

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UNIV-BOURGOGNE | PAM | INC-CNRS | ICMUB | AGROSUP-PAM | AGROSUP-DIJON

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Nicolas Sok, Maria Nikolantonaki, Stéphane Guyot, Thanh Dat Nguyen, Anne-Sophie Viaux, et al.. Design of new sensitive α,β-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging. Sensors and Actuators B: Chemical, Elsevier, 2017, 242, pp.865 - 871. 〈10.1016/j.snb.2016.09.171〉. 〈hal-01509840〉

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