Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Sonja I. Berndt 1, * Nicola J. Camp Christine F. Skibola Joseph Vijai Zhaoming Wang Jian Gu Alexandra Nieters Rachel S. Kelly Karin E. Smedby Alain Monnereau Wendy Cozen Angela Cox Sophia S. Wang Qing Lan Lauren R. Teras Moara Ma Meredith Ye Angela R. Brooks-Wilson Patricia Hartge Mark Ma Brenda M. Birmann Claire M. Vajdic Pierluigi Cocco Yawei Zhang Graham G. Giles Anne Zeleniuch-Jacquotte Charles Lawrence Rebecca Montalvan Laurie Burdett Amy Hutchinson Yuanqing Ye Timothy G. Call Tait D. Shanafelt Anne Novak Neil E. Kay Julie M. Cunningham Cristine Allmer Henrik Hjalgrim Hans-Olov Adami Mads Ma Bengt Glimelius Ellen T. Chang Martha Ma Karen Curtin Lisa A. Cannon-Albright W Ryan Diver Brian K. Link George J. Weiner Lucia Conde Paige M. Bracci Jacques Riby Donna K. Arnett Degui Zhi Justin M. Leach Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Núria Sala Delphine Casabonne Nikolaus Becker Paolo Boffetta Paul Brennan Lenka Foretova Marc Maynadié 2, 3 James Mckay Anthony Staines Kari G. Chaffee Sara J. Achenbach Celine M. Vachon Lynn R. Goldin Sara S. Strom Jose F. Leis J. Brice Weinberg Neil E. Caporaso Aaron D. Norman Anne De Roos Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Rudolph Kaaks Giovanna Ma Elisabete Weiderpass María- Dolores Ma Roel C. H. Vermeulen Ruth C. Travis Melissa C. Southey Roger L. Milne Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Jacqueline Clavel Tongzhang Zheng Theodore R. Holford Danylo J. Villano Ann Ma John J. Spinelli Randy D. Gascoyne Joseph M. Connors Kimberly A. Bertrand Edward Giovannucci Peter Kraft Anne Kricker Jenny Turner Maria Grazia Ma Giovanni M. Ferri Lucia Miligi Liming Liang Baoshan Ma Jinyan Huang Simon Crouch Ju-Hyun Park Nilanjan Chatterjee Kari E. North John A. Snowden Josh Wright Joseph F. Fraumeni Kenneth Offit Xifeng Wu Silvia De Sanjose James R. Cerhan Stephen J. Chanock Nathaniel Rothman Susan L. Slager 4
Abstract : Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
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Nature Communications, Nature Publishing Group, 2016, 7, 〈https://www.nature.com/articles/ncomms10933〉. 〈10.1038/ncomms10933〉
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Soumis le : vendredi 21 avril 2017 - 16:58:45
Dernière modification le : vendredi 8 juin 2018 - 14:50:17

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Sonja I. Berndt, Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, et al.. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nature Communications, Nature Publishing Group, 2016, 7, 〈https://www.nature.com/articles/ncomms10933〉. 〈10.1038/ncomms10933〉. 〈hal-01511871〉

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