Arrêt de service lundi 11 juillet de 12h30 à 13h : tous les sites du CCSD (HAL, EpiSciences, SciencesConf, AureHAL) seront inaccessibles (branchement réseau à modifier)

Article dans une revue

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Philip J Law Sonja I Berndt ¹ Helen Speedy Nicola J Camp Georgina P Sava Chris Skibola Amy Holroyd ² Vijai Joseph ³ Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R Goldin Guillem Clot ⁴ Lauren R Teras Inés Quintela Brenda M Birmann Sandrine Jayne Wendy Cozen Aneela Majid ⁵ Karin E Smedby Qing Lan Claire Dearden Angel Brooks-Wilson Andrew G. Hall ⁶ Mark Purdue Tryfonia Mainou-Fowler Claire M Vajdic Graham H Jackson ⁷ Pierluigi Cocco Helen Marr yawei Zhang ⁸ Tongzhang Zheng Graham G Giles ⁹ Charles Lawrence ¹⁰ Timothy G Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri ¹¹ Martha Glenn ¹² Karen Curtin W Ryan Diver Brian K Link ¹³ Lucia Conde Paige M Bracci Elizabeth A Holly Rebecca D Jackson Lesley F Tinker yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadié ¹⁴ James Mckay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E Caporaso Lindsay M Morton Richard Severson Elio Riboli Paolo Vineis Roel C H Vermeulen Melissa C Southey Roger L Milne Jacqueline Clavel ¹⁵ Sabine Topka John J Spinelli Peter Kraft Maria Grazia Ennas ¹⁶ Geoffrey Summerfield Giovanni M Ferri Robert J Harris ¹⁷ Lucia Miligi Andrew R Pettitt Kari E North David J Allsup Joseph F Fraumeni James R Bailey ¹⁸ Kenneth Offit Guy Pratt ¹⁹ Henrik Hjalgrim Chris Pepper ²⁰ Stephen J Chanock Chris Fegan Richard Rosenquist ¹¹ Silvia de Sanjose Ángel Carracedo ²¹ Martin J S Dyer ²² Daniel Catovsky ²³ Elias Campo James R Cerhan ²⁴ James M Allan ²⁵ Nathanial Rothman Richard Houlston ^{26, *} Susan Slager ^{24, *}

* Auteur correspondant

1 NCI-NIH - National Cancer Institute [Bethesda]

2 Microsoft Research [Redmond]

3 Department of Physics, Loyola College, Nungambakkam, Chennai – 600 034

4 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer

5 University of Aleppo [Aleppo]

6 SMRU - Sea Mammal Research Unit [University of St Andrews]

7 Department of Chemical Engineering

8 MONARIS - De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies

9 The Cancer Council Victoria

10 University of Oulu

11 Uppsala Universitet [Uppsala]

12 UPN - Université Paris Nanterre

13 University of Iowa [Iowa City]

14 Registre des hémopathies malignes de Côte d'Or

15 IRSN - Institut de Radioprotection et de Sûreté Nucléaire

16 B.B. Brodie Department of Neuroscience

17 Penn State - Pennsylvania State University

18 UoN - University of Newcastle [Australia]

19 AIM (UMR_7158 / UMR_E_9005 / UM_112) - Astrophysique Interprétation Modélisation

20 Department of Haematology, School of Medicine

21 CIBER de Enfermedades Raras (CIBERER)

22 University of Leeds

23 Haemato-oncology

24 Mayo Clinic [Rochester]

25 NICR - Northern Institute for Cancer Research [Newcastle]

26 Institute of Cancer Research, Belmont, Sutton

Abstract : Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Autre [q-bio.OT]

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01545767
Contributeur : LNC - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : dimanche 3 janvier 2021 - 08:31:39
Dernière modification le : mardi 18 janvier 2022 - 14:26:07
Archivage à long terme le : : dimanche 4 avril 2021 - 18:05:52

Vignette du document

ncomms14175.pdf

Fichiers éditeurs autorisés sur une archive ouverte