Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors

Abstract : The combination of anticancer drugs and metal oxide nanoparticles is of great interest in cancer nanomedicine. Here, the development of a new nanohybrid, titanate nanotube-docetaxel (TiONts-DTX) is reported, the two parts of which are conjugated by covalent linkages. Unlike most nanoparticles currently being developed for biomedical purposes, TiONts present a needle-shaped morphology. The surface of TiONts is linked with 3-aminopropyl triethoxysilane and with a hetero-bifunctional polymer (polyethylene glycol) to create well-dispersed and biocompatible nanovectors. The prefunctionalized surface of this scaffold has valuable attachments to graft therapeutic agents (DTX in our case) as well as chelating agents (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) to monitor the nanohybrids. To evaluate drug efficacy, in vitro tests have demonstrated that the association between TiONts and DTX shows cytotoxic activity against a hormone-refractory prostate cancer cell line (22Rv1) whereas TiONts without DTX do not. Finally, the first in vivo tests with intratumoral injections show that more than 70% of TiONts nanovectors are retained within the tumor for at least 7 d. Moreover, tumor growth in mice receiving TiONts-DTX is significantly slower than that in mice receiving free DTX. This nanohybrid can thus become a promising new tool in biomedicine to fight against prostate cancer.
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01553114
Contributeur : Le2i - Université de Bourgogne <>
Soumis le : lundi 3 juillet 2017 - 14:33:09
Dernière modification le : jeudi 11 janvier 2018 - 06:28:16

Identifiants

Collections

Citation

Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange, Nadine Millot. Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors. Advanced Healthcare Materials, Wiley, 2017, 〈http://onlinelibrary.wiley.com/doi/10.1002/adhm.201700245/abstract;jsessionid=BFCF1F191962EB8D83F6152EB3486E7C.f04t04?systemMessage=Wiley+Online+Library+%27Journal+Subscribe+%2F+Renew%27+page+will+be+down+on+Wednesday+05th+July+starting+at+08.00+EDT+%2F+13.00+BST+%2F+17.30+IST+for+up+to+75+minutes+due+to+essential+maintenance.〉. 〈10.1002/adhm.201700245〉. 〈hal-01553114〉

Partager

Métriques

Consultations de la notice

65