Synthesis and characterization of cobalt ferrites nanoparticles with cytotoxic and antimicrobial properties

Abstract : Recently, the application of nanotechnology in food sector and the agriculture attract the attention compared to its biomedical application. The aims of the current study was to synthesize and characterize cobalt ferrites nanoparticles [(CoFe2O4) NPs] by combustion method employing glycine as fuels and to evaluate their antimicrobial against pathogenic bacteria and fungi and anti cancer properties against MCF-7 breast cancer cells line. The results indicated that the particles size of the synthesized (CoFe2O4) NPs was 40 nm. These (CoFe2O4) NPs showed potential antibacterial properties against Gram-negative bacteria (Escherichia coli, Salmonella typhi) and Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus) as well as the pathogenic fungi (Aspergillus flavus and Aspergillus ochraceus) in a dose dependent manner with maximum concentration of 1.8 mg/ml. (CoFe2O4) NPs also showed weak antiradical but have cytotoxic effects against MCF-7 breast cancer cells line and succeeded to decrease the cell viability at a concentration of 2 mg/ml. It could be concluded that (CoFe2O4) NPs is a promise candidate as antimicrobial and anticancer agent for food sector and medical application.
Type de document :
Article dans une revue
Journal of applies pharmaceutical science, MediPoeia, 2017, 7 (01), 〈http://www.japsonline.com/abstract.php?article_id=2121〉. 〈10.7324/JAPS.2017.70111 〉
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01559150
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : lundi 10 juillet 2017 - 14:29:52
Dernière modification le : mercredi 13 décembre 2017 - 14:20:33

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Amal S. Hathout, Abdulhadi Aljawish, Bassem A. Sabry, Aziza A. El-Nekeety, Mohamed H. Roby, et al.. Synthesis and characterization of cobalt ferrites nanoparticles with cytotoxic and antimicrobial properties . Journal of applies pharmaceutical science, MediPoeia, 2017, 7 (01), 〈http://www.japsonline.com/abstract.php?article_id=2121〉. 〈10.7324/JAPS.2017.70111 〉. 〈hal-01559150〉

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