Outcome of Non-Invasive Brain Stimulation in Substance Use Disorders: A Review of Randomized Sham-Controlled Clinical Trials

Benoit Trojak (1, 2) , Anne Sauvaget (3) , Shirley Fecteau (4) , Laurence Lalanne (5) , Jean-Christophe Chauvet-Gelinier (2) , Sonja Koch , Samuel Bulteau (3) , Daniele Zullino (6, 7, 8) , Sophia Achab (6, 7, 8)

1 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
2 Service de psychiatrie générale et addictologie [CHU de Dijon]
3 Service d'addictologie[CHU Nantes]
4 CIRRIS - Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale
5 Service de psychiatrie, santé mentale et addictologie [CHU de Strasbourg]
6 Department of Mental Health and Psychiatry
7 UNIGE - Université de Genève = University of Geneva
8 Neuroscience Center [University of Geneva]

Non-invasive brain stimulation (NIBS) might be a new approach to treat substance use disorders (SUD). A systematic review and critical analysis was performed to identify potential therapeutic effects of NIBS on addictions. A search of the Medline database was conducted for randomized sham-controlled trials using NIBS in the field of addiction and published until August 2016. Twenty-six studies in various SUD met the inclusion criteria. Converging evidence indicates that NIBS might be a promising mean to treat patients with alcohol and tobacco use disorders, by acting on craving reduction and other mechanisms such as improvement in cognitive dysfunctions.

Mots clés: transcranial magnetic stimulation; dorsolateral prefrontal cortex; alcohol-dependent patients; theta burst stimulation; hf-rtms session; decision-making; methodological considerations; cigarette consumption; cortical stimulation; nicotine dependence; Alcohol Abuse and Dependence; Drug/Substance Abuse; ECT

Domaines: Sciences du Vivant [q-bio]; Neurosciences [q-bio.NC]

Benoit Trojak, Anne Sauvaget, Shirley Fecteau, Laurence Lalanne, Jean-Christophe Chauvet-Gelinier, et al.. Outcome of Non-Invasive Brain Stimulation in Substance Use Disorders: A Review of Randomized Sham-Controlled Clinical Trials. Journal of Neuropsychiatry and Clinical Neurosciences, 2017, 29 (2), pp.105 - 118. ⟨10.1176/appi.neuropsych.16080147⟩. ⟨hal-01563787⟩