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Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis.

Abstract : Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and MVs are garnering increasing attention because of their ability to participate in cellular communication or transfer of bioactive molecules (mRNAs, microRNAs, DNA and proteins) between neighboring cancerous or normal cells, and to contribute to human cancer progression. Malignant traits can also be transferred from apoptotic cancer cells to phagocytizing cells, either professional or non-professional. In this review, we focus on Exos and ABs and their relationship with human papillomavirus (HPV)-associated tumor development. The potential implication of EVs as theranostic biomarkers is also addressed.
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Soumis le : jeudi 27 mai 2021 - 16:30:20
Dernière modification le : lundi 28 novembre 2022 - 10:38:07
Archivage à long terme le : : samedi 28 août 2021 - 19:56:24


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David Guenat, François Hermetet, Jean-Luc Prétet, Christiane Mougin. Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis.. Viruses, 2017, 9 (8), pp.e211. ⟨10.3390/v9080211⟩. ⟨hal-01576136⟩



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