Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.

Jean-François Emile 1, * Catherine Julié 2 Karine Le Malicot 3 Come Lepage 4, 5, 6 Josep Tabernero 7 Enrico Mini 8 Gunnar Folprecht 9 Jean-Luc van Laethem 10 Stéphanie Dimet Camille Boulagnon-Rombi Marc-Antoine Allard 11 Frédérique Penault-Llorca 12 Jaafar Bennouna 13, 14 Pierre Laurent-Puig 15 Julien Taieb Jos Thaler 16 Richard Greil 17 Johannes Gaenzer Wolfgang Eisterer Joerg Tschmelitsch Felix Keil 18 Hellmut Sa August Zabernigg Franz Schmid 19 Günther Steger 20 Rob Steinacher Johannes Andel 21 Björn Jagdt Alois Lang Michael Fridrik 22 Reinhold Függer Friedrich Hofbauer Ewald Woell Dietmar Geissler 23 Alfred Lenauer Manfred Prager 24 Geert d'Haens Gauthier Demolin Josep Kerger Guido Deboever Gilbert Gil 25 Marc Polus Eric van Cutsem 26, 27 Hassan Rezaie Kalantari 28 Thierry Delaunoit Jean Charles Goeminne Marc Peeters 29 Philippe Vergauwe Ghislain Houbiers Yves Humblet Jan Janssens Dirk Schrijvers 30 Erik Vanderstraeten 31 Jan Vermorken 32 Daniel van Daele Michel Michel F. Forget 33 Alain Hendlisz Mette Yilmaz 34 Svend Erik Nielsen 35 Lene Vestermark 36, 37 Jim Larsen 38 Mohamed Zawadi Olivier Bouche 39 Laurent Mineur Jaafar Bennouna-Louridi Louis Marie Dourthe Marc Ychou 40 Eveline Boucher 41 Denis Denis 42 Francoise Desseigne Patrick Texereau 43 Laurent Miglianico Philippe Rougier 44 Serge Fratte 45 Charles-Briac Levache 46 Yacine Merrouche 47 Stephen Ellis Christophe Locher 48 Jean-Francois Ramee 49 Claire Garnier 50 Frederic Viret 51 Bruno Chauffert 52 Isabelle Cojean-Zelek 53 Pierre Michel 54 Cedric Lecaille Christian Borel 55 Jean-Francois Seitz 56 Catherine Lombard-Bohas 57 Thierry Andre 58, 59 Jean-Marc Gornet 60 Francine Fein 61 Marie-Aude Coulon-Sfairi Marie-Christine Kaminsky 62 Jean-Paul Lagasse Dominique Luet 43 Pierre Etienne 63 Mohamed Gasmi 64 Andre Vanoli Suzanne Nguyen 65 Thomas Aparicio 66 Hervé Perrier Noel Stremsdoerfer Philippe Laplaige 67 Dominique Arsene 68 Dominique Auby 69 Laurent Bedenne 70 Romain Coriat 71 Patrick Geoffroy 72, 73 Gilles Gil 25 Yves Becouarn 74 Gael Deplanque 75 Olivier Dupuis 76 Frederic Fruge Rosine Guimbaud 77 Thierry Lecomte 78 Gérard Lledo 79, 40 Iradej Sobhani 80 Amani Asnacios 81 Ahmed Azzedine Christophe Desauw Pierre Galais Dany Gargot You-Heng Lam Abakar Abakar-Mahamat Jean-Francois Berdah 82 Sylviane Catteau Marie-Christine Clavero-Fabri Jean-Francois Codoul Jean-Louis Legoux 83 Denis Goldfain Pierre Guichard 84 Denis Verge 85 Jocelyne Provencal Bruno Vedrenne Catherine Brezault-Bonnet Denis Cleau 61 Jean-Paul Desir 86 David Fallik Bruno Garcia Marie-Hélène Gaspa Dominique Genet 87 Johannes Hartwig Yves Krummel 88 Tamara Matysiak Budnik Vanessa Palascak-Juif 89 Harizo Randrianarivelo Yves Rinaldi 90 Albert Aleba Ariane Darut-Jouve Aimery de Gramont 58 Herve Hamon Frederic Wendehenne Axel Matzdorff 91 Michael Stahl Wolfgang Schepp Martin Burk Lothar Mueller 92 Michael Geissler Luis Mantovani Thomas Hoehler 93 Walter Asperger Hendrik Kroening Ludwig Fischer von Weikersthal Stefan Fuxius Matthias Groschek Johannes Meiler 94 Tanja Trarbach Jacqueline Rauh Nicola Ziegenhagen Albrecht Kretzschmar 95 Ullrich Graeven Arnd Nusch Goetz von Wichert Ralf-Dieter Hofheinz Gerhard Kleber Karl-Heinz Schmidt 96 Ursula Vehling-Kaiser Claudia Baum 97 Jochen Schuette Georg Haag 98 Wilhelm Holtkamp Jochen Potenberg Tobias Reiber Georg Schliesser Hans-Joachim Schmoll Wolfgang Schneider-Kappus Wolfgang Abenhardt Claudio Denzlinger Henning Henning Bartscht Marxsen Hans Guenter Derigs Helmut Lambertz Ingulf Becker-Boost Karel Caca Christian Constantin Thomas Decker 99 Henning Eschenburg Sigrun Gabius Holger Hebart 100 Albrecht Hoffmeister 101 Heinz-August Horst 102 Stephan Kremers Malte Leithaeuser Sebastian Mueller 103 Siegfried Wagner 104 Severin Daum 105 Frank Schlegel Martina Stauch 106 Volker Heinemann Evaristo Maiello Luciano Latini Alberto Zaniboni Dino Amadori 107 Giuseppe Aprile Sandro Sa 108 Rodolfo Mattioli Andrea Martoni Rodolfo Passalacqua Mario Nicolini 109 Enzo Pasquini Carla Rabbi Enrico Aitini Alberto Ravaioli 110 Carlo Barone 111 Guido Biasco Stefano Tamberi Angelo Gambi 112 Claudio Verusio Marina Marzola 113 Giorgio Lelli Corrado Boni 114 Stefano Cascinu 115 Paolo Bidoli Massimo Vaghi Giorgio Cruciani Francesco Costa 116 Alberto Sobrero Rob Petrioli Massimo Aglietta Oscar Alabiso Federico Capuzzo Alfredo Falcone Domenico Cristi Corsi 117 Rob Labianca 118 Stefania Sa 108 Silvana Chiara Libero Ciuffreda Francesco Ferraù 119 Francesco Giuliani Sara Sa 108 Nicola Gebbia Giovanni Mantovani Evaristo Sa Juan Carlos Mellidez Pedro Sa Joao Freire Cristina Sa 120, 121 Luis Costa 122 Antonio Moreira Pinto 123, 124 Sergio Barroso Jorge Espirito Sa Fátima Guedes Amélia Monteiro 125 Anabela Sa 126 Irene Furtado 127 Ramon Salazar Enrique Aranda Aguilar 128, 129 Fernando Rivera Herrero Javier Valera Manuel Valladares Ayerbes Jaime Feliu Batlle Silvia Gil 130 Albert Abad Esteve 131 Carlos Garcia Guillermo Lopez Lopez 132 Antonia Salud Salvia Vicente Alonso Orduña Ruth Vera Garcia 133 Javier Gallego Bartomeu Massuti Sureda Jordi Remon 134 Maria Jose Safont Aguilera Luis Cirera Nogueras Bernado Queralt Merino 135 Cristina Gravalos Castro 136 Purificacion Martinez Martinez 137 Carlos Pijaume Pericay Manuel Constenla Figueiras Inmaculada Guasch Jordan 138 Maria Jose Gome Reina Amelia Lopez-Ladron Garcia 139 Antonio Arrivi Garcia 140 Andres Cervantes 141 Carlos Fernandez Martos Eugenio Marcuello Gaspa Ines Cabezas Montero 133 Pilar Escudero Emperador Ana Leon Carbonero Manuel Gallen Castillo 142 Teresa Garcia Garcia 143 Jose Garcia Garcia Encarnacion Gonzalez Flores Monica Guillot Morales 144 Marta Llanos Muñoz 122 Ana López Martín Joan Maurel Juan Carlos Camara 145 Rosario Dueñas Garcia 133 Mercedes Salgado Isabel Hernandez Busquier Teresa Checa Ruiz 146 Adelaida Lacasta Muñoa Miquel Nogue Aliguer Amalia Velasco Ortiz de Taranco Miguel Mendez Ureña Ferran Losa Gaspa Jose Juan Ponce 147 Carlos Bosch Roig Jim Jimenez 148 Antonio Galan Brotons 149 Santiago Albiol Rodriguez 150 Jose Ales Martinez Liliana Canosa Ruiz 151 Margarita Centelles Ruiz 152, 153 John Bridgewater Rob Glynne-Jones Saad Tahir Tamas Hickish Jim Cassidy 154 Leslie Samuel
* Auteur correspondant
109 FEEM
120 NIPE
130 CARE - IRCELYON-Catalytic and Atmospheric Reactivity for the Environment
IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon
Abstract : BackgroundThe prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use.Patients and methodsAccording to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI (#NCT02364024). Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Automated testing of LI was performed on virtual slides without access to clinical data.ResultsAmong the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02). Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS. Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients.ConclusionAlthough this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01579009
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 30 août 2017 - 11:28:21
Dernière modification le : mercredi 15 septembre 2021 - 11:08:06

Identifiants

Citation

Jean-François Emile, Catherine Julié, Karine Le Malicot, Come Lepage, Josep Tabernero, et al.. Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.. European Journal of Cancer, Elsevier, 2017, 82, pp.16-24. ⟨10.1016/j.ejca.2017.04.025⟩. ⟨hal-01579009⟩

Partager

Métriques

Consultations de la notice

9653