Is functional mobility an independent mortality risk factor in subjects with dementia?

Abstract : Objective: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia. Study design: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible. Those with a diagnosis of dementia were considered in the analyses. Main outcome measures: Patients' characteristics obtained through comprehensive geriatric assessment performed during the first week of hospitalisation. Functional mobility was assessed using the timed "Up & Go" test. The main outcome was time to death within the 12 months of follow-up. Bivariable relationships between each risk factor and mortality were assessed using a Cox regression model with one explanatory variable. For multivariable analysis, the Cox regression model was used in a stepwise method after examining potential confoUnders and interactions. Results: In all, 589 patients had a diagnosis of dementia, and were considered in the present analyses. Their mean age was 86 6 years and most (69%) were female. The prevalence of functional mobility disorders was 86%. After 12 months, 232 (39%) had died. After adjustment for potential confounders, functional mobility was associated with a significantly higher risk of 12-month mortality (HR = 1.66; 95% CI = 1.02-2.71; p = 0.04). Conclusions: Impaired functional mobility as assessed by the timed Up & Go test identifies subjects with dementia at risk of unfavourable outcome.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01588534
Contributeur : Caps - Université de Bourgogne <>
Soumis le : vendredi 15 septembre 2017 - 17:39:41
Dernière modification le : vendredi 8 juin 2018 - 14:50:17

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Rachid Mahmoudi, Jean-Luc Novella, Patrick Manckoundia, Faiza Ahssaini, Pierre-Olivier Lang, et al.. Is functional mobility an independent mortality risk factor in subjects with dementia?. Maturitas, Elsevier, 2017, 103, pp.65 - 70. 〈http://www.sciencedirect.com/science/article/pii/S0378512216304571?via%3Dihub〉. 〈10.1016/j.maturitas.2017.06.031〉. 〈hal-01588534〉

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