Is functional mobility an independent mortality risk factor in subjects with dementia?

Rachid Mahmoudi; Jean-Luc Novella; Patrick Manckoundia; Faiza Ahssaini; Pierre-Olivier Lang; François Blanchard; Damien Jolly; Moustapha Dramé

doi:10.1016/j.maturitas.2017.06.031

Article dans une revue

Is functional mobility an independent mortality risk factor in subjects with dementia?

Rachid Mahmoudi ^{1, 2, *} Jean-Luc Novella ^{1, 2} Patrick Manckoundia ^{3, 4} Faiza Ahssaini ¹ Pierre-Olivier Lang ⁵ François Blanchard ^{1, 2} Damien Jolly ² Moustapha Dramé ²

* Auteur correspondant

1 Département de médecine interne et de gérontologie, Hôpital Maison Blanche, Reims

2 SPVQVRSF - Santé publique, vieillissement, qualité de vie et réadaptation des sujets fragiles - EA 3797

3 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]

4 Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD)

5 Service de gériatrie et réadaptation gériatrique (Centre Hospitalier Universitaire Vaudois, Lausanne)

Abstract : Objective: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia. Study design: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible. Those with a diagnosis of dementia were considered in the analyses. Main outcome measures: Patients' characteristics obtained through comprehensive geriatric assessment performed during the first week of hospitalisation. Functional mobility was assessed using the timed "Up & Go" test. The main outcome was time to death within the 12 months of follow-up. Bivariable relationships between each risk factor and mortality were assessed using a Cox regression model with one explanatory variable. For multivariable analysis, the Cox regression model was used in a stepwise method after examining potential confoUnders and interactions. Results: In all, 589 patients had a diagnosis of dementia, and were considered in the present analyses. Their mean age was 86 6 years and most (69%) were female. The prevalence of functional mobility disorders was 86%. After 12 months, 232 (39%) had died. After adjustment for potential confounders, functional mobility was associated with a significantly higher risk of 12-month mortality (HR = 1.66; 95% CI = 1.02-2.71; p = 0.04). Conclusions: Impaired functional mobility as assessed by the timed Up & Go test identifies subjects with dementia at risk of unfavourable outcome.

Keywords : elderly-patients older-adults gait disorders SAFES cohort Mortality Functional mobility Elderly Dementia go test falls prevalence community balance alzheimers severity

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Gériatrie et gérontologie

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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01588534
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Soumis le : vendredi 15 septembre 2017 - 17:39:41
Dernière modification le : mercredi 3 novembre 2021 - 06:54:23

Is functional mobility an independent mortality risk factor in subjects with dementia?

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