Is functional mobility an independent mortality risk factor in subjects with dementia?

Rachid Mahmoudi 1, 2, * Jean-Luc Novella 1, 2 Patrick Manckoundia 3, 4 Faiza Ahssaini 1 Pierre-Olivier Lang 5 François Blanchard 1, 2 Damien Jolly 2 Moustapha Dramé 2
* Auteur correspondant
1 Département de médecine interne et de gérontologie, Hôpital Maison Blanche, Reims
2 SPVQVRSF - Santé publique, vieillissement, qualité de vie et réadaptation des sujets fragiles - EA 3797
3 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
4 Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD)
5 Service de gériatrie et réadaptation gériatrique (Centre Hospitalier Universitaire Vaudois, Lausanne)
Abstract : Objective: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia. Study design: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible. Those with a diagnosis of dementia were considered in the analyses. Main outcome measures: Patients' characteristics obtained through comprehensive geriatric assessment performed during the first week of hospitalisation. Functional mobility was assessed using the timed "Up & Go" test. The main outcome was time to death within the 12 months of follow-up. Bivariable relationships between each risk factor and mortality were assessed using a Cox regression model with one explanatory variable. For multivariable analysis, the Cox regression model was used in a stepwise method after examining potential confoUnders and interactions. Results: In all, 589 patients had a diagnosis of dementia, and were considered in the present analyses. Their mean age was 86 6 years and most (69%) were female. The prevalence of functional mobility disorders was 86%. After 12 months, 232 (39%) had died. After adjustment for potential confounders, functional mobility was associated with a significantly higher risk of 12-month mortality (HR = 1.66; 95% CI = 1.02-2.71; p = 0.04). Conclusions: Impaired functional mobility as assessed by the timed Up & Go test identifies subjects with dementia at risk of unfavourable outcome.
Keywords : Dementia Elderly Functional mobility Mortality SAFES cohort gait disorders older-adults elderly-patients go test falls prevalence community balance alzheimers severity
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01588534
Contributeur : Caps - Université de Bourgogne <>
Soumis le : vendredi 15 septembre 2017 - 17:39:41
Dernière modification le : vendredi 8 juin 2018 - 14:50:17

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UNIV-BOURGOGNE | U1093 | URCA | VIEFRA | CAPSANTE

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Rachid Mahmoudi, Jean-Luc Novella, Patrick Manckoundia, Faiza Ahssaini, Pierre-Olivier Lang, et al.. Is functional mobility an independent mortality risk factor in subjects with dementia?. Maturitas, Elsevier, 2017, 103, pp.65 - 70. ⟨10.1016/j.maturitas.2017.06.031⟩. ⟨hal-01588534⟩

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