Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin

Pensak Jantrawut; Tanpong Chaiwarit; Kittisak Jantanasakulwong; Claire Brachais; Odile Chambin

doi:10.3390/polym9070289

Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin

Pensak Jantrawut ^{1, *} Tanpong Chaiwarit ¹ Kittisak Jantanasakulwong ² Claire Brachais ³ Odile Chambin ⁴

* Auteur correspondant

1 Department of Pharmaceutical Sciences [Chiang Mai]

2 School of agro-industry [Chiang Mai]

3 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]

4 PAM - Procédés Alimentaires et Microbiologiques [Dijon]

Abstract : This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young’s modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness.

Keywords : behavior low-methoxyl pectin indomethacin glycerin propylene glycol chitosan films transition glycerol delivery

Type de document :

Article dans une revue

Polymers, MDPI, 2017, 9 (7), pp.289. 〈10.3390/polym9070289〉

Domaine :

Sciences du Vivant [q-bio] / Ingénierie des aliments

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01618709
Contributeur : Pam - Université de Bourgogne <>
Soumis le : mercredi 18 octobre 2017 - 12:35:29
Dernière modification le : vendredi 15 février 2019 - 11:27:42

Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin

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Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin

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