Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation

Abstract : Ubiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast. It contributes to the rapid adaptation of the cells to physiological intracellular variations and to intracellular or environmental stresses. E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. Its expression and activity are tightly regulated over the course of the cell cycle progression and in response to genotoxic stress. I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1's regulation.
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International Journal of Molecular Sciences, MDPI, 2017, 18 (10), 〈http://www.mdpi.com/1422-0067/18/10/2188〉. 〈10.3390/ijms18102188〉
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01632423
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 10 novembre 2017 - 10:50:06
Dernière modification le : mercredi 13 décembre 2017 - 14:20:33

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Laurence Dubrez. Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation. International Journal of Molecular Sciences, MDPI, 2017, 18 (10), 〈http://www.mdpi.com/1422-0067/18/10/2188〉. 〈10.3390/ijms18102188〉. 〈hal-01632423〉

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