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Predominance of G9P[8] Rotavirus Strains throughout France, 2014-2017

Jérôme Kaplon 1, 2, 3, * Nadège Grangier 2, 3 Sylvie Pillet 4, 3 Adissa Minoui-Tran 5, 3 Astrid Vabret 6, 3 Nathalie Wilhelm 7, 3 Nathalie Prieur 8, 3 Mouna Lazrek 9, 3 Sophie Alain 10, 3, 11 Yahia Mekki 12, 3 Vincent Foulongne 13, 3, 14 Jérôme Guinard 15, 3 Véronique Avettand-Fenoel 16, 3 Aurélie Schnuriger 17, 3 Agnès Beby-Defaux 18, 3 Gisèle Lagathu 19, 3 Pierre Pothier 2, 3 Alexis de Rougemont 1, 3, * 
Abstract : OBJECTIVES: Group A rotavirus is a major cause of acute gastroenteritis in young children worldwide. A prospective surveillance network has been set up in France to investigate rotavirus infections and to detect the emergence of potentially epidemic strains. METHODS: From 2014 to 2017, rotavirus-positive stool samples were collected from 2394 children under 5 years old attending the paediatric emergency units of 13 large hospitals. Rotaviruses were genotyped by RT-PCR with regard to their outer capsid proteins VP4 and VP7. RESULTS: Genotyping of 2421 rotaviruses showed that after a marked increase in G9P[8] (32.1%) during the 2014-2015 season, G9P[8] became the predominant genotype during the 2015-2016 and 2016-2017 seasons with detection rates of 64.1% and 77.3%, respectively, whilst G1P[8] were detected at low rates of 16.8% and 6.6%, respectively. Phylogenetic analysis of the partial rotavirus VP7 and VP4 coding genes revealed that all these G9P[8] strains belonged to the lineage III and the P[8]-3 lineage, respectively, and shared the same genetic background (G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) as did most of previously detected G9P[8] strains and particularly the emerging G9P[8] strains from the 2004-2005 season in France. CONCLUSIONS: G9P[8] rotaviruses have become the predominant circulating genotype for the first time since their emergence a decade ago. In the absence of rotavirus immunisation programmes in France, our data give an insight into the natural fluctuation of rotavirus genotypes in a non-vaccinated population and provide a base line for a better interpretation of data in European countries with routine rotavirus vaccination.
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Soumis le : mercredi 22 novembre 2017 - 17:38:00
Dernière modification le : jeudi 20 octobre 2022 - 15:10:07

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Jérôme Kaplon, Nadège Grangier, Sylvie Pillet, Adissa Minoui-Tran, Astrid Vabret, et al.. Predominance of G9P[8] Rotavirus Strains throughout France, 2014-2017. Clinical Microbiology and Infection, 2018, pp.660.e1-660.e4. ⟨10.1016/j.cmi.2017.10.009⟩. ⟨hal-01645002⟩



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