Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses

Abstract : Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and VO2 peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited. Cognitive function assessment included short term- working memory, perceptual abilities, processing speed, cognitive inhibition and flexibility and long-term verbal memory. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamic (impedance cardiography) and left frontal cerebral oxygenation-perfusion (near-infra red spectroscopy) were measured during and after a maximal incremental ergocycle test. Compared to OHC and CHD, YHC had higher VO2 peak, maximal cardiac index (CI max), cerebral oxygenation-perfusion (Delta O-2 Hb, Delta tHb: exercise and recovery) and cognitive function (for all items) (P< 0.05). Compared to OHC, CHD patients had lower VO2 peak, CI max, cerebral oxygenation- perfusion (during recovery) and short term-working memory, processing speed, cognitive inhibition and flexibility and long-term verbal memory (P< 0.05). VO2 peak and CI max were related to exercise cerebral oxygenation-perfusion and cognitive function (P< 0.005). Cerebral oxygenation-perfusion (exercise) was related to cognitive function (P< 0.005). Stable CHD patients have a worse cognitive function, a similar cerebral oxygenation/ perfusion during exercise but reduced one during recovery vs. their aged-matched healthy counterparts. In the all sample, cognitive functions correlated with VO2 peak, CI max and cerebral oxygenation-perfusion.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01652235
Contributeur : Caps - Université de Bourgogne <>
Soumis le : jeudi 30 novembre 2017 - 09:54:09
Dernière modification le : jeudi 26 juillet 2018 - 14:08:02

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Mathieu Gayda, Vincent Gremeaux, Louis Bherer, Martin Juneau, Joffrey Drigny, et al.. Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses. PLoS ONE, Public Library of Science, 2017, 12 (9), 〈http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183791〉. 〈10.1371/journal.pone.0183791〉. 〈hal-01652235〉

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