Impact of graft preservation solutions for liver transplantation on early cytokine release and postoperative organ dysfunctions. A pilot study

H. Brisson (1, 2) , C. Arbelot (1) , A. Monsel (1) , C. Parisot (2) , M. Girard (1) , E. Savier (1, 3) , C. Vezinet (1) , Q. Lu (1) , J.-C. Vaillant (1) , J.-L. Golmard (4) , G. Gorochov (2) , O. Langeron (1) , J.-J. Rouby (1) , G. Rousseau (1) , M. Siksik (1) , P. Lebray (1) , M. Rudler (1) , D. Thabut (1) , T. Poynard (1) , B. Bouhemad (5) , D. Eyraud (1) , O. Gostian (1) , S. Fratea (1) , B. Barrou (1)

1 CHU Pitié-Salpêtrière [AP-HP]
2 Immunité et Infection
3 IRTOMIT - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques
4 ER4 - Modeling in Clinical Research
5 Service d'anesthésie - réanimation chirurgicale [CHU de Dijon]

Introduction: During liver transplantation, graft ischemia-reperfusion injury leads to a systemic inflammatory response producing postoperative organ dysfunctions. The aim of this observational and prospective study was to compare the impact of Solution deconservation des organeset tissus (SCOT) 15 and University of Wisconsin (UW) preservation solutions on early cytokine release, postreperfusion syndrome and postoperative organ dysfunctions.& para;& para;Methods: Thirty-seven liver transplantations were included: 21 in UW Group and 16 in SCOT 15 group. Five cytokines were measured in systemic blood after anesthetic induction, 30 minutes after unclamping portal vein and on postoperative day 1.& para;& para;Results: Following unclamping portal vein, cytokines were released in systemic circulation. Systemic cytokine concentrations were higher in UW than in SCOT 15 group: Interleukin-10, lnterleukine-6. In SCOT 15 group, significant reduction of postreperfusion syndrome incidence and acute kidney injury were observed. Alanine and aspartate aminotransferase peak concentrations were higher in SCOT 15 group than in UW group. However, from postoperative day 1 to day 10, aminotransferase returned to normal values and did not differ between groups.& para;& para;Conclusions: Compared to UW, SCOT 15 decreases systemic cytokine release resulting from graft ischemia-reperfusion injury and reduces incidence of postreperfusion syndrome and post operative renal failure. (C) 2017 Published by Elsevier Masson SAS.

Mots clés: Ischemia-Reperfusion Injury; Acute Kidney Injury; Of-Wisconsin Solution; Polyethylene-Glycol; Postreperfusion Syndrome; Ischemia/Reperfusion Injury; Hepatic Ischemia; Term Survival; Cold Ischemia; Risk-Factors

Domaines: Hépatologie et Gastroentérologie

H. Brisson, C. Arbelot, A. Monsel, C. Parisot, M. Girard, et al.. Impact of graft preservation solutions for liver transplantation on early cytokine release and postoperative organ dysfunctions. A pilot study. Clinics and Research in Hepatology and Gastroenterology, 2017, 41 (5), pp.564 - 574. ⟨10.1016/j.clinre.2016.12.011⟩. ⟨hal-01664906⟩