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Article dans une revue

Effects of anti-somatostatin agents on glucose metabolism

Abstract : The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57–73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. In acromegaly, treatment with pasireotide induces hyperglycaemia in 29–61% of patients. Pasireotide-induced hyperglycemia occurs early, within the first 3 months of treatment, due to a decrease in insulin secretion secondary to a fall in secretion of GLP-1 and GIP, and potentially also due to a direct inhibitory effect of pasireotide on beta cells. Close monitoring of blood glucose is mandatory in all patients during the first 3 months of treatment with pasireotide. Where necessary, antidiabetic treatment should be initiated, preferably with a DPP-4 inhibitor or a GLP-1 receptor agonist, both of which have proven efficacy in the control of hyperglycaemia induced by pasireotide.
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Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01678259
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mardi 9 janvier 2018 - 10:21:17
Dernière modification le : vendredi 8 juin 2018 - 14:50:25

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B. Vergès. Effects of anti-somatostatin agents on glucose metabolism. Journal of Diabetes & Metabolism, OMICS International, 2017, 43 (5), pp.411 - 415. ⟨10.1016/j.diabet.2017.05.003⟩. ⟨hal-01678259⟩

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