Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era

Abstract : Objective: Non-Hodgkin's lymphoma (NHL) remains among the most frequent malignancies in persons living with HIV (PLWHIV). Survival among patients with HIV-associated diffuse large B-cell lymphoma (DLBCL), the most frequent NHL subtype, has improved markedly in recent years. We aimed to analyze characteristics and outcomes of DLBCL in HIV-infected patients in the era of modern combined antiretroviral therapy (cART). Design: PLWHIV with lymphoma were prospectively enrolled in the French ANRS-CO16 Lymphovir cohort between 2008 and 2015. We compared the patients treated with R-CHOP) (rituximab, cyclophosphamide, daunorubicin, vin-cristine, prednisolone) with HIV-negative DLBCL patients enrolled simultaneously in the R-CHOP arms of Lymphoma Study Association trials. Results: Among 110 PLWHIV with NHL, 52 (47%) had systemic DLBCL. These 52 cases had frequent extranodal disease (81%), poor performance status (35%) and advanced age-adjusted international prognostic index (aaIPI) (58%), and were mainly treated with R-CHOP (n = 44, 85%). Their median CD4(+) T-cell count was 233 cells/mu l, and 79% of patients were on cART. The 2-year overall and progression-free survival rates were both 75% (95% confidence interval: 64%, 88%). Factors associated with progression or death in univariate analysis were poor performance status [hazard ratio: 3.3 (1.2, 8.9)], more than one extranodal site [hazard ratio: 3.4 (1.1, 10.5)] and an advanced aaIPI [hazard ratio: 3.7 (1.0, 13.1)]. Progression-free survival after R-CHOP therapy did not differ from that of the HIV-negative counterparts (P = 0.11). Conclusion: In the recent cART era, despite frequent high-risk features, the 2-year overall survival of HIV-DLBCL patients reaches 75%. Outcomes after R-CHOP therapy are similar to those of HIV-negative patients with similar aaIPI. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01683121
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 12 janvier 2018 - 18:23:38
Dernière modification le : lundi 29 avril 2019 - 15:20:06

Identifiants

Citation

Caroline Besson, Rémi Lancar, Sophie Prevot, Michele Algarte-Genin, Pierre Delobel, et al.. Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era. AIDS, Lippincott, Williams & Wilkins, 2017, 31 (18), pp.2493 - 2501. ⟨http://journals.lww.com/aidsonline/Abstract/2017/11280/Outcomes_for_HIV_associated_diffuse_large_B_cell.7.aspx⟩. ⟨10.1097/QAD.0000000000001652⟩. ⟨hal-01683121⟩

Partager

Métriques

Consultations de la notice

268