Y. Ninomiya and M. Funakoshi, Behavioral discrimination between glutamate and the four basic taste substances in mice, Comp Biochem Physiol A Comp Physiol, vol.92, issue.3, pp.365-70, 1989.

J. R. Stapleton, M. Luellig, S. D. Roper, and E. R. Delay, Discrimination between the tastes of sucrose and monosodium glutamate in rats, Chem Senses, vol.27, issue.4, pp.375-82, 2002.

G. Hellekant, V. Danilova, and Y. Ninomiya, Primate sense of taste: behavioral and single chorda tympani and glossopharyngeal nerve fiber recordings in the rhesus monkey, Macaca mulatta, J Neurophysiol, vol.77, issue.2, pp.978-93, 1997.

V. Danilova, T. Roberts, and G. Hellekant, Responses of single taste fibers and whole chorda tympani and glossopharyngeal nerve in the domestic pig, Sus scrofa, Chem Senses, vol.24, issue.3, pp.301-317, 1999.

D. M. Kendig, N. R. Hurst, Z. L. Bradley, S. Mahavadi, J. F. Kuemmerle et al., Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon, Am J Physiol Gastrointest Liver Physiol, vol.307, issue.11, pp.1100-1107, 2014.

E. Roura, B. Humphrey, K. Klasing, and M. Swart, Is the pig a good umami sensing model for humans? A comparative taste receptor study, Flavour Frag J, vol.26, issue.4, pp.282-287, 2011.

X. Li, L. Staszewski, H. Xu, K. Durick, M. Zoller et al., Human receptors for sweet and umami taste, Proc Natl Acad Sci, vol.99, issue.7, pp.4692-4698, 2002.

G. Nelson, J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao et al., An amino-acid taste receptor, Nature, vol.416, issue.6877, pp.199-202, 2002.

S. Yamaguchi, Basic properties of umami and effects on humans, Physiol Behav, vol.49, issue.5, pp.833-874, 1991.

G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. Ryba et al., Mammalian sweet taste receptors, Cell, vol.106, issue.3, pp.381-90, 2001.

H. Xu, L. Staszewski, H. Tang, E. Adler, M. Zoller et al., Different functional roles of T1R subunits in the heteromeric taste receptors, Proc Natl Acad Sci U S A, vol.101, issue.39, pp.14258-63, 2004.

F. Zhang, B. Klebansky, R. M. Fine, H. Xu, A. Pronin et al., Molecular mechanism for the umami taste synergism, Proc Natl Acad Sci U S A, vol.105, issue.52, pp.20930-20934, 2008.

N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto et al., Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor, Nature, vol.407, issue.6807, pp.971-978, 2000.

N. Nuemket, N. Yasui, Y. Kusakabe, Y. Nomura, N. Atsumi et al., Structural basis for perception of diverse chemical substances by T1r taste receptors, Nat Commun, vol.8, p.15530, 2017.

Y. Toda, T. Nakagita, T. Hayakawa, S. Okada, M. Narukawa et al., Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor). The Journal of biological chemistry, vol.288, pp.36863-77, 2013.

E. R. Delay and T. Kondoh, Dried bonito dashi: taste qualities evaluated using conditioned taste aversion methods in wild-type and T1R1 knockout mice, Chem Senses, vol.40, issue.2, pp.125-165, 2015.

Y. Kusuhara, R. Yoshida, T. Ohkuri, K. Yasumatsu, A. Voigt et al., Taste responses in mice lacking taste receptor subunit T1R1, J Physiol, vol.591, issue.7, pp.1967-85, 2013.

P. Choudhuri, S. Delay, R. J. Delay, and E. R. , L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors, PLoS One, vol.10, issue.6, p.130088, 2015.

L. N. Saites, Z. Goldsmith, J. Densky, V. A. Guedes, and J. D. Boughter, Mice perceive synergistic umami mixtures as tasting sweet, Chem Senses, vol.40, issue.5, pp.295-303, 2015.

N. Chaudhari, E. Pereira, and S. D. Roper, Taste receptors for umami: the case for multiple receptors, Am J Clin Nutr, vol.90, issue.3, pp.738-780, 2009.

Y. Maruyama, E. Pereira, R. F. Margolskee, N. Chaudhari, and S. D. Roper, Umami responses in mouse taste cells indicate more than one receptor, J Neurosci, vol.26, issue.8, pp.2227-2261, 2006.

W. Lei, A. Ravoninjohary, X. Li, R. F. Margolskee, D. R. Reed et al., Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLoS One, vol.10, issue.10, p.139670, 2015.

M. M. Sandau, J. R. Goodman, A. Thomas, J. B. Rucker, and N. E. Rawson, A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs, BMC Neurosci, vol.16, p.26037485, 2015.

J. Bradshaw, Sensory and experiential factors in the design of foods for domestic dogs and cats, Proc Nutr Soc, vol.50, issue.01, pp.99-106, 1991.

J. Bradshaw, The Evolutionary Basis for the Feeding Behavior of Domestic Dogs (Canis familiaris) and Cats (Felis catus), J Nutr, vol.136, issue.7, pp.1927-1958, 2006.

S. Mcgrane, C. Hernangomez-de-alvaro, M. Gibbs, R. Fine, B. Klebansky et al., , 2014.

, Understanding Cat Umami Flavour Perception Through in vivo and in silico Studies, Current Topics in Flavor Chemistry and Biology. Proc. Conf. 10th Wartburg Symposium on Flavor Chemistry and Biology, pp.35-40, 2013.

T. D. White and J. C. Boudreau, Taste preferences of the cat for neurophysiologically active compounds, Physiol Psychol, vol.3, issue.4, pp.405-415, 1975.

S. Mcgrane, A. Taylor, . Mars, and . Inc, Waltham Centre for Pet Nutrition, GB), assignee. Flavour Additives, 2014.

K. Yoshii, C. Yokouchi, and K. Kurihara, Synergistic effects of 5'-nucleotides on rat taste responses to various amino acids, Brain Res, vol.367, issue.1-2, pp.45-51, 1986.

X. Li, W. Li, H. Wang, J. Cao, K. Maehashi et al., Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar, PLoS Genet, vol.1, issue.1, pp.27-35, 2005.

A. A. Bachmanov, N. P. Bosak, C. Lin, I. Matsumoto, M. Ohmoto et al., Genetics of taste receptors, Curr Pharm Des, vol.20, issue.16, pp.2669-83, 2014.

R. Li, W. Fan, G. Tian, H. Zhu, L. He et al., The sequence and de novo assembly of the giant panda genome, Nature, vol.463, issue.7279, pp.311-318, 2010.

M. W. Baldwin, Y. Toda, T. Nakagita, M. J. O'connell, K. C. Klasing et al., Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor, Science, vol.345, issue.6199, pp.929-962, 2014.

T. Ariyasu, S. Matsumoto, F. Kyono, T. Hanaya, S. Arai et al., Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose, In Vitro Cell Dev Biol Anim, vol.39, issue.1-2, pp.80-88, 2003.

E. Maitrepierre, M. Sigoillot, L. Pessot, L. Briand, and L. , Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptor, Protein Expr Purif, vol.83, issue.1, pp.75-83, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01296425

E. Maitrepierre, M. Sigoillot, L. Pessot, L. Briand, and L. , An efficient Escherichia coli expression system for the production of a functional N-terminal domain of the T1R3 taste receptor, Bioengineered, vol.4, issue.1, pp.25-34, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00866018

Y. Nie, S. Vigues, J. R. Hobbs, G. L. Conn, and S. D. Munger, Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli, Curr Biol, vol.15, issue.21, pp.1948-52, 2005.

M. Raliou, M. Grauso, B. Hoffmann, C. Schlegel-le-poupon, C. Nespoulous et al., Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function, Chem Senses, vol.36, issue.6, pp.527-564, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00641823

U. K. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, vol.227, issue.5259, pp.680-685, 1970.

L. Whitmore and B. A. Wallace, DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data, Nucleic Acids Res, vol.32, pp.668-73, 2004.

Y. Nie, J. R. Hobbs, S. Vigues, W. J. Olson, G. L. Conn et al., Expression and purification of functional ligand-binding domains of T1R3 taste receptors, Chem Senses, vol.31, issue.6, pp.505-518, 2006.

Y. Huang, Y. Zhou, A. Castiblanco, W. Yang, E. M. Brown et al., Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response, Biochemistry, vol.48, issue.2, pp.388-98, 2009.

Y. Suzuki, E. Moriyoshi, D. Tsuchiya, and H. Jingami, Negative cooperativity of glutamate binding in the dimeric metabotropic glutamate receptor subtype 1. The Journal of biological chemistry, vol.279, pp.35526-35560, 2004.

A. Kuninaka, Studies on taste of ribonucleic acid derivatives, J Agri Chem Soc Jpn, vol.34, issue.7, pp.487-92, 1960.

A. Kuninaka, The Nucleotides, a Rationale of Research on Flavor Potentiation, Studies on taste of ribonucleic acid derivatives. Symposium on Flavor Potentiation1964, pp.4-9

M. Sato and N. Akaike, 5'-ribonucleotides as gustatory stimuli in rats electrophysiological studies, Jpn J Physiol, vol.15, issue.1, pp.53-70, 1965.

Y. Geng, D. Xiong, L. Mosyak, D. L. Malito, J. Kniazeff et al., Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2, Nat Neurosci, vol.15, issue.7, pp.970-978, 2012.

Y. Geng, L. Mosyak, I. Kurinov, H. Zuo, E. Sturchler et al., Structural mechanism of ligand activation in human calcium-sensing receptor, eLife, vol.5, 2016.

X. Li, M. Inoue, D. R. Reed, T. Huque, R. B. Puchalski et al., High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4, Mamm Genome, vol.12, issue.1, pp.13-19, 2001.

F. Zhang, B. Klebansky, R. M. Fine, H. Liu, H. Xu et al., Molecular mechanism of the sweet taste enhancers, Proc Natl Acad Sci U S A, vol.107, issue.10, pp.4752-4759, 2010.

T. M. Nelson, S. D. Munger, and J. D. Boughter, Taste sensitivities to PROP and PTC vary independently in mice, Chem Senses, vol.28, issue.8, pp.695-704, 2003.

G. K. Beauchamp, Characterization of the N-terminal domain of the cat T1R1 umami taste receptor, Am J Clin Nutr, vol.90, issue.3, pp.723-730, 2009.