Similarities between induced membrane and amniotic membrane: Novelty for bone repair

Florelle Gindraux 1, 2, * Thomas Rondot 1 Benoit de Billy 3, 2, 4 Narcisse Zwetyenga 5 Jean-Christophe Fricain 6 Aurélie Pagnon 7 Laurent Obert 1, 2, 3
* Auteur correspondant
1 Service de Chirurgie Orthopédique Traumatologique et Plastique [Besançon]
2 NIT / NANOMEDECINE - Nanomédecine, imagerie, thérapeutique - UFC (EA 4662)
3 SFR FED 4234 - Structure fédérative de recherche : Ingénierie et biologie cellulaire et tissulaire (Université de Franche-Comté)
4 Service de chirurgie pédiatrique [CHU Besançon]
5 Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
6 INSERM UMR-S1026, Bioingénierie Tissulaire, Université Bordeaux
7 NOVOTEC (Lyon)
Abstract : Previous clinical studies have shown the efficacy of a two-stage surgical procedure - the induced membrane (IM) technique - for reconstruction of large bone defects or bone non-union. The first stage involves radical debridement and insertion of a cement spacer into the bone defect. The second stage, performed weeks to months later, consists of removing the spacer while leaving the foreign body membrane induced by the cement in place, and then filling the cavity with bone autograft. The IM has been shown to (1) act as a protective physical barrier by preventing bone autograft resorption and (2) act as a bioreactor by promoting healing through revascularisation and growth factor secretion, and by concentrating mesenchymal stem cells (MSC) with osteogenic properties. New solutions to reduce this surgical procedure to a single step are being explored, for example by using an IM-like bioactive and protective barrier inserted into the bone defect at the same time as bone graft.
Keywords : Amnion Bioreactor Bone repair Induced membrane like bioactive Masquelet technique Protective barrier
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01688857
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 19 janvier 2018 - 17:58:38
Dernière modification le : lundi 17 septembre 2018 - 17:47:38

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Florelle Gindraux, Thomas Rondot, Benoit de Billy, Narcisse Zwetyenga, Jean-Christophe Fricain, et al.. Similarities between induced membrane and amniotic membrane: Novelty for bone repair. Placenta, Elsevier, 2017, 59, pp.116 - 123. ⟨10.1016/j.placenta.2017.06.340⟩. ⟨hal-01688857⟩

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