Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Expressed fusion gene landscape and its impact in multiple myeloma

Abstract : Multiple myeloma is a plasma cell malignancy characterized by recurrent IgH translocations and well described genomic heterogeneity. Although transcriptome profiles in multiple myeloma has been described, landscape of expressed fusion genes and their clinical impact remains unknown. To provide a comprehensive and detailed fusion gene cartography and suggest new mechanisms of tumorigenesis in multiple myeloma, we performed RNA sequencing in a cohort of 255 newly diagnosed and homogeneously treated multiple myeloma patients with long follow-up. Here, we report that patients have on average 5.5 expressed fusion genes. Kappa and lambda light chains and IgH genes are main partners in a third of all fusion genes. We also identify recurrent fusion genes that significantly impact both progression-free and overall survival and may act as drivers of the disease. Lastly, we find a correlation between the number of fusions, the age of patients and the clinical outcome, strongly suggesting that genomic instability drives prognosis of the disease.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01697367
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mardi 8 juin 2021 - 14:46:17
Dernière modification le : lundi 21 juin 2021 - 15:29:36

Fichier

s41467-017-00638-w.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

A. Cleynen, R. Szalat, M. Kemal Samur, S. Robiou Du Pont, L. Buisson, et al.. Expressed fusion gene landscape and its impact in multiple myeloma. Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.1893. ⟨10.1038/s41467-017-00638-w⟩. ⟨hal-01697367⟩

Partager

Métriques

Consultations de la notice

289

Téléchargements de fichiers

25