Duration of treatment with bisphosphonates at the time of osteonecrosis of the jaw onset in patients with rheumatoid arthritis. Review.

Abstract : Introduction Rheumatoid arthritis (RA) is a frequent and co-morbid condition. One of the main complications is induced osteoporosis. Treatments related to this complication significantly modify oral and implant management. Affected patients represent a population at intermediate risk of osteonecrosis of the jaw (ONJ). The objective was to search the literature for durations of treatment with bisphosphonates at the time of ONJ occurrence in patients with RA in order to obtain an average duration. Materials And Methods A bibliographic search in the PUBMED/MEDLINE database was carried out using the following equation “(osteonecrosis) AND jaw) AND rheumatoid arthritis” with no time limitation. The primary study endpoint was the duration of treatment with bisphosphonates (BP) at the time of ONJ onset in patients with RA. Results 12 articles accounting for 50 patients were included. Patients had had a median of 46.8 months of treatment with BP before ONJ occurred. Mean, minimum and maximum treatment times were 48.68, 6 and 120 months, respectively. The standard deviation was 27.77 months. Discussion The median treatment duration in our cohort of patients with RA was less than that reported for osteoporosis. We therefore recommend that practitioners take additional precautions regarding oral surgery or implant procedures, particularly in patients with RA who have been treated with BP for more than 4 years.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01707703
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mardi 13 février 2018 - 09:25:07
Dernière modification le : vendredi 12 octobre 2018 - 11:16:05

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Hugo Compain, Alexandre Berquet, Ludwig-Stanislas Loison-Robert, Victorin Ahossi, Narcisse Zwetyenga. Duration of treatment with bisphosphonates at the time of osteonecrosis of the jaw onset in patients with rheumatoid arthritis. Review.. Journal of Stomatology, Oral and Maxillofacial Surgery, Elsevier Masson, 2018, 119 (3), pp.177-181. ⟨https://www.sciencedirect.com/science/article/pii/S2468785518300016?via%3Dihub⟩. ⟨10.1016/j.jormas.2017.12.009⟩. ⟨hal-01707703⟩

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